Association between height-related polymorphism rs17081935 and reduced handgrip strength in relation to status of atherosclerosis: a cross-sectional study

Table 3 Odds ratios (ORs) and 95% confidence intervals (CIs) for reduced handgrips strength in relation to rs17081935 genotypes by atherosclerosis

	rs17081935 genotypes			p	Minor allele (T)	[p]^b
	(C/C)	(C/T)	(T/T)	p	Minor allele (T)	[p]^b
Atherosclerosis ( −)
No. of participants	452	475	149
No. of case (%)	75 (16.6)	101 (21.3)	26 (17.4)
Height^a (standard error)	155.0 (0.3)	155.0 (0.3)	155.9 (0.5)	0.186
Erythrocyte, × 10⁴/μL	447 ± 40	441 ± 40	441 ± 44	0.098
Model 1	Ref	1.38 (0.97, 1.95)	1.08 (0.64, 1.81)	0.353	1.12 (0.89, 1.41)	0.057
Model 2	Ref	1.38 (0.97, 1.96)	1.08 (0.64, 1.82)	0.350	1.12 (0.89, 1.41)	0.786
Model 3	Ref	1.34 (0.94, 1.92)	1.11 (0.65, 1.90)	0.343	1.13 (0.86, 1.43)	0.424
Model 4	Ref	1.35 (0.94, 1.93)	1.12 (0.65, 1.91)	0.329	1.13 (0.89, 1.44)	0.402
Atherosclerosis ( +)
No. of participants	128	129	41
No. of case (%)	46 (35.9)	30 (23.3)	7 (17.1)
Height^a (standard error)	156.2 (0.5)	156.3 (0.5)	158.2 (0.9)	0.116
Erythrocyte, × 10⁴/μL	438 ± 41	446 ± 46	450 ± 37	0.158
Model 1	Ref	0.51 (0.29, 0.91)	0.33 (0.13, 0.84)	0.005	0.55 (0.37, 0.83)	0.379
Model 2	Ref	0.47 (0.26, 0.85)	0.32 (0.12, 0.81)	0.003	0.53 (0.34, 0.81)	0.588
Model 3	Ref	0.46 (0.25, 0.84)	0.38 (0.15, 0.99)	0.008	0.55 (0.36, 0.86)	0.712
Model 4	Ref	0.48 (0.27, 0.88)	0.40 (0.16, 1.01)	0.010	0.57 (0.37, 0.88)	0.951

^a Sex and age adjusted values of height. ^bP for good for fit test evaluated by the Hosmer–Lemeshow test. Ref: reference. Model 1, adjusted only for sex and age. Model 2, adjusted further for drinking status (non, often, daily), smoking status (never, former, current), BMI status (< 18.0 kg/m², 18.0–24.9 kg/m², and 25 kg/m² ≤), hypertension, dyslipidemia, diabetes. Model 3, further adjusted for height. Model 4, adjusted only for sex, age, height, and renal function (< 60 mL/min/1.73 m², 60–89 mL/min/1.73m², 90 ml/min/1.73m² ≤)

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