Associations between handgrip strength and hypertension in relation to circulating CD34-positive cell levels among Japanese older men: a cross-sectional study

Table 3 Odds ratios (ORs) and 95% confidence intervals (CIs) for systolic hypertension in relation to handgrip strength stratified by circulating CD34-positive cell count

	Handgrip strength levels			p for trend	p (goodness of fit test)	1 SD increment of handgrip strength (kg)
	T1 (low)	T2	T3 (high)	p for trend	p (goodness of fit test)	1 SD increment of handgrip strength (kg)
High CD34-positive cell count (≥ 0.96 cells/μL)
No. of participants	37	49	43
No. of cases (%)	11 (29.7)	22 (44.9)	22 (51.2)
Age-adjusted ORs	1.00	1.97 (0.80, 4.88)	2.62 (1.03, 6.69)	0.046	0.882	1.81 (1.18, 2.77)
Multivariable ORs	1.00	2.43 (0.88, 6.68)	2.74 (0.97, 7.73)	0.063	0.475	1.88 (1.19, 2.99)
Low CD34-positive cell count (< 0.96 cells/μL)
No. of participants	49	39	40
No. of cases (%)	24 (49.0)	13 (33.3)	14 (35.0)
Age-adjusted ORs	1.00	0.48 (0.20, 1.19)	0.51 (0.20, 1.26)	0.135	0.250	0.88 (0.62, 1.26)
Multivariable ORs	1.00	0.43 (0.16, 1.19)	0.41 (0.14, 1.21)	0.098	0.691	0.87 (0.58, 1.33)
		Interaction*		p
Age-adjusted model		1.90 (1.11, 3.25)		0.020
Multivariable model		2.05 (1.25, 3.89)		0.007

Systolic hypertension is defined as systolic blood pressure ≥ 140 mmHg. Multivariable ORs: adjusted further for age and BMI, anti-hypertensive medication, HDLc, TG, γ-GTP, WBC, HbA1c, and GFR. BMI body mass index, HDLc HDL-cholesterol, TG triglycerides, HbA1c hemoglobin A1c, γ-GTP γ-glutamyltranspeptidase, WBC white blood cell, GFR glomerular filtration rate. Handgrip strength tertiles are as follows: < 37.0 kg for T1, 37.0–41.9 kg for T2, and ≥ 42.0 kg for T3. *The effect of interaction between circulating CD34-positive cell levels and handgrip strength (1 SD increment: 6.0kg) on systolic hypertension

ISSN: 1347-4715