Table 3 Prenatal chemical exposure and association with adipocytokines at birth
From: Hokkaido birth cohort study on environment and children’s health: cohort profile 2021
Biological specimens and exposure level (ng/ml, median, IQR) | Findings | Ref. | |
|---|---|---|---|
PFOS | Maternal blood at 2nd–3rd trimester 5.1 (3.7–6.7) | Positively associated with total adiponectin levels (β=0.12, 95% CI 0.01, 0.22) | [37] |
MEHP | Maternal blood at 2nd–3rd trimester 8.81 (5.45–13.3) | Positively associated with adiponectin level among boys (β = 4.63, 95% CI 0.77, 8.94). Negatively associated with leptin level among girls (β = −0.31, 95% CI −0.52, −0.10). | [38] |
MEHP | Maternal blood at 1st trimester 1.50 (0.82–9.35) | Inversely associated with the leptin levels (β=0.08, 95%CI −0.14, −0.03). | [39] |
MnBP | Maternal blood at 1st trimester 26.0 (17.0–37.0) | Inversely associated with leptin level (β = −0.12, 95%CI −0.24, 0.00) | [39] |
MiBP | Maternal blood at 1st trimester 6.95 (4.60–9.58) | Inversely associated with leptin level (β=-0.14, 95%CI −0.27, −0.01). | [39] |
BPA | Maternal blood at 1st trimester 0.060 (0.023–0.250) | Negatively associated with the leptin level (β = −0.06, 95% confidence interval [CI] −0.11, −0.01) and positively associated with the high-molecular-weight adiponectin level (β = 0.03, 95%CI 0.00, 0.06). | [39] |