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Table 2 Follow-up studies (Sapporo and Hokkaido cohorts)

From: Hokkaido birth cohort study on environment and children’s health: cohort profile 2021

 

Questionnaire Survey

Face-to-face examinations

Specimen/sample collections

Exposure measurements

Neurobehavioral development

Allergy/infections

Anthropometric measurements/puberty

Sapporo cohort

 6–7 months

EES

  

BSID-II, FTII,

  

 1.5 years

EES

ISAAC, ATS-DLD, infections

Physical growth

BSID-II, DDST,

  

 3.5 years

CBCL, EES

ISAAC, infections

Physical growth

K-ABC, WAIS-R,

  

 7 years

CBCL, J-PSAI, 2D/4D

ISAAC, infections

Physical growth

WISC-III, WCST-KFS,

  

 12 years

Tanner staging, onset

 

Tanner staging, onset of puberty

Event-related brain potentials: 11–14 years

Urine of children (9–12)

Neonicotinoids

 13 years

  

Physical growth during elementary school

   

Hokkaido cohort

 4 months

Physical Growth

     

 1 year

 

ISAAC, ATS-DLD, infections

Physical growth

   

 1.5 years

KIDS, M-CHAT

     

 2 years

 

ISAAC, infections

Physical growth

   

 3 years

KIDS, SDQ

     

 4 years

 

ISAAC, infections

Physical growth

   

 5 years

SDQ, DCDQ

     

 6 years

ADHD-RS, ASQ (SCQ)

     

 7 years

 

ISAAC

Health checkup data

 Home visit

Urine of children/house dust

Urine: Phthalates, PFRs, Bisphenols, Alternative plasticizers, Neonicotinoids, and organophosphate pesticides

House dust: Phthalates, alternative plasticizers, and PFRs

 8 years

ADHD-RS, Conners 3P,

 

CBCL, WISC-IV

   

 9–11 years

 

ISAAC, history of vaccination

 

Medical examination phase 1 (Blood pressure, anthropometric examination, FeNO, ISAAC)

Peripheral blood/urine of children

Urine: Phthalates, PFRs, Bisphenols, Alternative plasticizers

Blood: PFAS

 12 years

SDQ / KIDSCREEN: 8–17 years

 

Tanner staging, onset of puberty

Event-Related Brain Potentials: 11–14 years

Urine of children/tap water

 

 13 years

  

Physical growth during elementary school

   

 16 years

 

ISAAC

Physical growth during junior high school

Medical examination phase 2 (Tanner staging, Blood pressure, anthropometric examination, Gripping power, 2D/4D, Consumer-product-use, Personal care products): 14–17 years

Peripheral blood/urine of children/house dust

 
  1. 2D/4D 2nd and 4th digits ratios, ADHD-RS Attention Deficit Hyperactivity Disorder-Rating Scale, ASQ Autism Screening Questionnaire, ATS-DLD American Thoracic Society-Division of Lung Disease, M-CHAT Modified Checklist for Autism in Toddlers, BSID-II Bayley Scales of Infant Development second edition, CBCL Child Behavior Checklist, Conners 3P Conner’s 3rd Edition for Parents, DCDQ Developmental Coordination Disorder Questionnaire, DDST Denver Developmental Screening Tests, EES Evaluation of Environmental Stimulation, FeNO Fractional exhaled nitric oxide, FTII Fagan Test of Infant Intelligence, ISAAC International Study of Asthma and Allergies in Childhood, J-PSAI Japanese Pre-School Activities Inventory, K-ABC Kaufman Assessment Battery for Children, KIDS Kinder Infant Development Scale, PFRs phosphate flame retardants, SCQ Social Communication Questionnaire, SDQ Strengths and Difficulties Questionnaire, WAIS-R Wechsler Adult Intelligence Scale-Revised, WISC-III Wechsler Intelligence Scale for Children third edition, WCST-KFS Wisconsin Card Sorting Test (Keio Version), WISC-IV Wechsler Intelligence Scale for Children fourth edition