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Table 3 Multivariable-adjusted hazard ratios of the log-transformed urinary NT-proBNP for the development of cardiovascular disease, stratified by presence or absence of traditional cardiovascular risk factors

From: Urinary N-terminal pro–B-type natriuretic peptide as a biomarker for cardiovascular events in a general Japanese population: the Hisayama Study

Subgroups Persons at risk No. of events Hazard ratio (95% CI) per 1-SD increment in log-transformed (log10) urinary NT-proBNPa P for heterogeneity
Overall 3055 169 1.20 (1.07–1.35)  
Age
 40–64 years 1691 32 1.21 (0.75–1.96) 0.44
 ≥ 65 years 1364 137 1.25 (1.11–1.41)
Sex
 Men 1286 92 1.21 (1.03–1.41) 0.48
 Women 1769 77 1.30 (1.08–1.57)
Hypertension
 No 1612 47 1.39 (1.06–1.81) 0.11
 Yes 1443 122 1.17 (1.02–1.33)
Use of antihypertensive agents
 No 2161 89 1.30 (1.09–1.56) 0.08
 Yes 894 80 1.16 (0.98–1.37)
Diabetes
 No 2597 122 1.26 (1.11–1.43) 0.24
 Yes 458 47 0.96 (0.71–1.29)
Hypercholesterolemia
 No 1610 79 1.20 (1.03–1.40) 0.54
 Yes 1445 90 1.13 (0.95–1.35)
Use of lipid-lowering drugs
 No 2630 130 1.19 (1.03–1.37) 0.65
 Yes 425 39 1.34 (1.07–1.67)
Body mass index (kg/m2)
 < 25 2268 117 1.25 (1.09–1.42) 0.38
 ≥ 25 787 52 1.18 (0.93–1.51)
eGFR level (mL/min/1.73 m2)
 ≥ 60 2742 130 1.30 (1.10–1.53) 0.07
 < 60 313 39 1.18 (1.00–1.39)
  1. The SD of log-transformed urinary NT-proBNP levels (pg/mL) was 0.215
  2. Abbreviations: SD Standard deviation, NT-proBNP N-terminal pro–B-type natriuretic peptide, CI Confidence interval, eGFR Estimated glomerular filtration rate
  3. aAdjusted for age, sex, systolic blood pressure, antihypertensive agents, diabetes mellitus, serum total and high-density lipoprotein cholesterol levels, lipid-lowering agents, body mass index, electrocardiogram abnormality, estimated glomerular filtration rate, smoking habits, alcohol intake, and regular exercise. The variable relevant to the subgroup was excluded from each model. Five participants with missing data for covariates were excluded from this analysis (n = 3055)