Urinary N-terminal pro–B-type natriuretic peptide as a biomarker for cardiovascular events in a general Japanese population: the Hisayama Study

Table 3 Multivariable-adjusted hazard ratios of the log-transformed urinary NT-proBNP for the development of cardiovascular disease, stratified by presence or absence of traditional cardiovascular risk factors

Subgroups	Persons at risk	No. of events	Hazard ratio (95% CI) per 1-SD increment in log-transformed (log₁₀) urinary NT-proBNP^a	P for heterogeneity
Overall	3055	169	1.20 (1.07–1.35)
Age
40–64 years	1691	32	1.21 (0.75–1.96)	0.44
≥ 65 years	1364	137	1.25 (1.11–1.41)	0.44
Sex
Men	1286	92	1.21 (1.03–1.41)	0.48
Women	1769	77	1.30 (1.08–1.57)	0.48
Hypertension
No	1612	47	1.39 (1.06–1.81)	0.11
Yes	1443	122	1.17 (1.02–1.33)	0.11
Use of antihypertensive agents
No	2161	89	1.30 (1.09–1.56)	0.08
Yes	894	80	1.16 (0.98–1.37)	0.08
Diabetes
No	2597	122	1.26 (1.11–1.43)	0.24
Yes	458	47	0.96 (0.71–1.29)	0.24
Hypercholesterolemia
No	1610	79	1.20 (1.03–1.40)	0.54
Yes	1445	90	1.13 (0.95–1.35)	0.54
Use of lipid-lowering drugs
No	2630	130	1.19 (1.03–1.37)	0.65
Yes	425	39	1.34 (1.07–1.67)	0.65
Body mass index (kg/m²)
< 25	2268	117	1.25 (1.09–1.42)	0.38
≥ 25	787	52	1.18 (0.93–1.51)	0.38
eGFR level (mL/min/1.73 m²)
≥ 60	2742	130	1.30 (1.10–1.53)	0.07
< 60	313	39	1.18 (1.00–1.39)	0.07

The SD of log-transformed urinary NT-proBNP levels (pg/mL) was 0.215
Abbreviations: SD Standard deviation, NT-proBNP N-terminal pro–B-type natriuretic peptide, CI Confidence interval, eGFR Estimated glomerular filtration rate
^aAdjusted for age, sex, systolic blood pressure, antihypertensive agents, diabetes mellitus, serum total and high-density lipoprotein cholesterol levels, lipid-lowering agents, body mass index, electrocardiogram abnormality, estimated glomerular filtration rate, smoking habits, alcohol intake, and regular exercise. The variable relevant to the subgroup was excluded from each model. Five participants with missing data for covariates were excluded from this analysis (n = 3055)

ISSN: 1347-4715