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Table 2 Age- and sex-adjusted and multivariable-adjusted hazard ratios for the development of cardiovascular disease and its subtypes according to urinary NT-proBNP levels

From: Urinary N-terminal pro–B-type natriuretic peptide as a biomarker for cardiovascular events in a general Japanese population: the Hisayama Study

Urinary NT-proBNP (pg/mL) Persons at risk No. of events Age- and sex-adjusted Multivariable-adjusteda
Hazard ratio (95% CI) P value Hazard ratio (95% CI) P value
Cardiovascular disease
 ≤ 19 1354 38 1.00 (reference)   1.00 (reference)  
 20–26 1105 59 1.25 (0.82–1.90) 0.30 1.30 (0.86–1.99) 0.22
 27–42 369 34 1.49 (0.90–2.47) 0.12 1.51 (0.91–2.51) 0.11
 ≥ 43 232 39 2.41 (1.44–4.04) < 0.001 2.07 (1.20–3.56) 0.009
P for trend     < 0.001   0.009
Coronary heart disease
 ≤ 19 1354 23 1.00 (reference)   1.00 (reference)  
 20–26 1105 26 0.98 (0.55–1.75) 0.93 1.01 (0.56–1.82) 0.97
 27–42 369 18 1.54 (0.77–3.04) 0.22 1.52 (0.76–3.06) 0.24
 ≥ 43 232 11 1.33 (0.59–3.00) 0.49 1.09 (0.45–2.63) 0.85
P for trend     0.28   0.52
Stroke
 ≤ 19 1354 15 1.00 (reference)   1.00 (reference)  
 20–26 1105 34 1.73 (0.93–3.21) 0.09 1.76 (0.95–3.29) 0.07
 27–42 369 17 1.67 (0.79–3.51) 0.18 1.66 (0.79–3.51) 0.18
 ≥ 43 232 28 3.81 (1.86–7.80) < 0.001 3.24 (1.54–6.85) 0.002
P for trend     < 0.001   0.004
  1. Abbreviations: NT-proBNP N-terminal pro–B-type natriuretic peptide, CI Confidence interval
  2. aAdjusted for age, sex, systolic blood pressure, antihypertensive agents, diabetes mellitus, serum total and high-density lipoprotein cholesterol levels, lipid-lowering agents, body mass index, electrocardiogram abnormality, estimated glomerular filtration rate, smoking habits, alcohol intake, and regular exercise. Five participants with missing data for covariates were excluded from the multivariable-adjusted analysis (n = 3055)