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Table 1 Age- and sex-adjusted clinical characteristics according to the urinary NT-proBNP levels at baseline

From: Urinary N-terminal pro–B-type natriuretic peptide as a biomarker for cardiovascular events in a general Japanese population: the Hisayama Study

Risk factors Overall (n = 3060) Urinary NT-proBNP levels (pg/mL) P for trend
≤ 19 (n = 1354) 20–26 (n = 1105) 27–42 (n = 369) ≥ 43 (n = 232)
Age, mean (SE), years 63 (0.2) 57 (0.3) 64 (0.3) 72 (0.6) 78 (0.7) < 0.001
Women, % 57.9 59.8 58.3 56.3 47.5 0.007
Systolic blood pressure, mean (SE), mmHg 132 (0.3) 132 (0.5) 131 (0.6) 131 (1.0) 133 (1.3) 0.77
Diastolic blood pressure, mean (SE), mmHg 79 (0.2) 80 (0.3) 79 (0.3) 79 (0.6) 78 (0.8) 0.01
Antihypertensive agents, % 29.3 24.8 28.0 27.0 30.6 0.10
Hypertension, % 47.3 45.7 46.4 49.8 54.1 0.06
Diabetes mellitus, % 15.0 14.5 14.2 12.8 13.9 0.61
Serum total cholesterol, mean (SE), mmol/L 5.43 (0.02) 5.53 (0.03) 5.43 (0.03) 5.29 (0.05) 5.08 (0.06) < 0.001
Serum HDL cholesterol, mean (SE), mmol/L 1.74 (0.01) 1.70 (0.01) 1.76 (0.01) 1.80 (0.02) 1.75 (0.03) 0.004
Lipid-lowering agents, % 13.9 12.3 12.7 9.0 8.8 0.04
Hypercholesterolemia, % 47.3 51.8 47.5 39.2 30.8 < 0.001
Body mass index, mean (SE), kg/m2 23.0 (0.1) 23.3 (0.1) 23.1 (0.1) 22.5 (0.2) 21.8 (0.2) < 0.001
Body mass index ≥ 25 kg/m2, % 25.8 27.4 26.5 21.0 19.4 0.006
Electrocardiogram abnormality, % 15.2 11.0 11.6 18.5 36.6 < 0.001
eGFR, mean (SE), mL/min/1.73 m2 75 (0.2) 75 (0.2) 75 (0.3) 74 (0.5) 70 (0.6) < 0.001
eGFR < 60 mL/min/1.73 m2, % 10.2 4.2 4.4 7.4 11.0 < 0.001
Current smoking, % 20.1 12.7 14.6 19.3 16.4 0.01
Current drinking, % 48.1 48.7 46.9 45.6 50.6 0.79
Regular exercise, % 12.0 12.1 12.6 11.7 6.8 0.10
Serum NT-proBNP, median (IQR), pg/mLa 56 (32–104) 33 (21–52) 65 (44–97) 135 (98–187) 424 (237.5–883.5) -
Urinary NT-proBNP, median (IQR), pg/mLa 20 (18–25) 17 (16–18) 22 (21–24) 31 (28–35) 70.5 (50.5–117.5) -
  1. Abbreviations: NT-proBNP N-terminal pro–B-type natriuretic peptide, SE Standard error, HDL High-density lipoprotein, eGFR Estimated glomerular filtration rate, IQR Interquartile range
  2. aValues were not adjusted for age and sex