Risk factors | Overall (n = 3060) | Urinary NT-proBNP levels (pg/mL) | P for trend | |||
---|---|---|---|---|---|---|
≤ 19 (n = 1354) | 20–26 (n = 1105) | 27–42 (n = 369) | ≥ 43 (n = 232) | |||
Age, mean (SE), years | 63 (0.2) | 57 (0.3) | 64 (0.3) | 72 (0.6) | 78 (0.7) | < 0.001 |
Women, % | 57.9 | 59.8 | 58.3 | 56.3 | 47.5 | 0.007 |
Systolic blood pressure, mean (SE), mmHg | 132 (0.3) | 132 (0.5) | 131 (0.6) | 131 (1.0) | 133 (1.3) | 0.77 |
Diastolic blood pressure, mean (SE), mmHg | 79 (0.2) | 80 (0.3) | 79 (0.3) | 79 (0.6) | 78 (0.8) | 0.01 |
Antihypertensive agents, % | 29.3 | 24.8 | 28.0 | 27.0 | 30.6 | 0.10 |
Hypertension, % | 47.3 | 45.7 | 46.4 | 49.8 | 54.1 | 0.06 |
Diabetes mellitus, % | 15.0 | 14.5 | 14.2 | 12.8 | 13.9 | 0.61 |
Serum total cholesterol, mean (SE), mmol/L | 5.43 (0.02) | 5.53 (0.03) | 5.43 (0.03) | 5.29 (0.05) | 5.08 (0.06) | < 0.001 |
Serum HDL cholesterol, mean (SE), mmol/L | 1.74 (0.01) | 1.70 (0.01) | 1.76 (0.01) | 1.80 (0.02) | 1.75 (0.03) | 0.004 |
Lipid-lowering agents, % | 13.9 | 12.3 | 12.7 | 9.0 | 8.8 | 0.04 |
Hypercholesterolemia, % | 47.3 | 51.8 | 47.5 | 39.2 | 30.8 | < 0.001 |
Body mass index, mean (SE), kg/m2 | 23.0 (0.1) | 23.3 (0.1) | 23.1 (0.1) | 22.5 (0.2) | 21.8 (0.2) | < 0.001 |
Body mass index ≥ 25 kg/m2, % | 25.8 | 27.4 | 26.5 | 21.0 | 19.4 | 0.006 |
Electrocardiogram abnormality, % | 15.2 | 11.0 | 11.6 | 18.5 | 36.6 | < 0.001 |
eGFR, mean (SE), mL/min/1.73 m2 | 75 (0.2) | 75 (0.2) | 75 (0.3) | 74 (0.5) | 70 (0.6) | < 0.001 |
eGFR < 60 mL/min/1.73 m2, % | 10.2 | 4.2 | 4.4 | 7.4 | 11.0 | < 0.001 |
Current smoking, % | 20.1 | 12.7 | 14.6 | 19.3 | 16.4 | 0.01 |
Current drinking, % | 48.1 | 48.7 | 46.9 | 45.6 | 50.6 | 0.79 |
Regular exercise, % | 12.0 | 12.1 | 12.6 | 11.7 | 6.8 | 0.10 |
Serum NT-proBNP, median (IQR), pg/mLa | 56 (32–104) | 33 (21–52) | 65 (44–97) | 135 (98–187) | 424 (237.5–883.5) | - |
Urinary NT-proBNP, median (IQR), pg/mLa | 20 (18–25) | 17 (16–18) | 22 (21–24) | 31 (28–35) | 70.5 (50.5–117.5) | - |