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Table 1 Age- and sex-adjusted clinical characteristics according to the urinary NT-proBNP levels at baseline

From: Urinary N-terminal pro–B-type natriuretic peptide as a biomarker for cardiovascular events in a general Japanese population: the Hisayama Study

Risk factors

Overall (n = 3060)

Urinary NT-proBNP levels (pg/mL)

P for trend

≤ 19 (n = 1354)

20–26 (n = 1105)

27–42 (n = 369)

≥ 43 (n = 232)

Age, mean (SE), years

63 (0.2)

57 (0.3)

64 (0.3)

72 (0.6)

78 (0.7)

< 0.001

Women, %

57.9

59.8

58.3

56.3

47.5

0.007

Systolic blood pressure, mean (SE), mmHg

132 (0.3)

132 (0.5)

131 (0.6)

131 (1.0)

133 (1.3)

0.77

Diastolic blood pressure, mean (SE), mmHg

79 (0.2)

80 (0.3)

79 (0.3)

79 (0.6)

78 (0.8)

0.01

Antihypertensive agents, %

29.3

24.8

28.0

27.0

30.6

0.10

Hypertension, %

47.3

45.7

46.4

49.8

54.1

0.06

Diabetes mellitus, %

15.0

14.5

14.2

12.8

13.9

0.61

Serum total cholesterol, mean (SE), mmol/L

5.43 (0.02)

5.53 (0.03)

5.43 (0.03)

5.29 (0.05)

5.08 (0.06)

< 0.001

Serum HDL cholesterol, mean (SE), mmol/L

1.74 (0.01)

1.70 (0.01)

1.76 (0.01)

1.80 (0.02)

1.75 (0.03)

0.004

Lipid-lowering agents, %

13.9

12.3

12.7

9.0

8.8

0.04

Hypercholesterolemia, %

47.3

51.8

47.5

39.2

30.8

< 0.001

Body mass index, mean (SE), kg/m2

23.0 (0.1)

23.3 (0.1)

23.1 (0.1)

22.5 (0.2)

21.8 (0.2)

< 0.001

Body mass index ≥ 25 kg/m2, %

25.8

27.4

26.5

21.0

19.4

0.006

Electrocardiogram abnormality, %

15.2

11.0

11.6

18.5

36.6

< 0.001

eGFR, mean (SE), mL/min/1.73 m2

75 (0.2)

75 (0.2)

75 (0.3)

74 (0.5)

70 (0.6)

< 0.001

eGFR < 60 mL/min/1.73 m2, %

10.2

4.2

4.4

7.4

11.0

< 0.001

Current smoking, %

20.1

12.7

14.6

19.3

16.4

0.01

Current drinking, %

48.1

48.7

46.9

45.6

50.6

0.79

Regular exercise, %

12.0

12.1

12.6

11.7

6.8

0.10

Serum NT-proBNP, median (IQR), pg/mLa

56 (32–104)

33 (21–52)

65 (44–97)

135 (98–187)

424 (237.5–883.5)

-

Urinary NT-proBNP, median (IQR), pg/mLa

20 (18–25)

17 (16–18)

22 (21–24)

31 (28–35)

70.5 (50.5–117.5)

-

  1. Abbreviations: NT-proBNP N-terminal pro–B-type natriuretic peptide, SE Standard error, HDL High-density lipoprotein, eGFR Estimated glomerular filtration rate, IQR Interquartile range
  2. aValues were not adjusted for age and sex