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Table 3 Association between internal dose of metals in quintiles and presence of a clinical outcome at birth, adjusted to maternal and newborn clinical background and SGA1,2

From: Maternal metal concentration during gestation and pediatric morbidity in children: an exploratory analysis

 

Metal (in quintiles)

Preterm delivery (n = 12) vs none (n = 97)

Asthma (n = 77) vs none (n = 34)

Cardiovascular (n = 12) vs none (n = 99)

Behavioral or developmental (n = 7) vs none (n = 104)

Obesity (n = 6) vs none (n = 105)

Malformations (n = 8) vs none (n = 103)

Biometals

Ca, ppm

0.91 (0.626)

1.07 (0.151)

0.92 (0.687)

1.70 (0.026)

0.98 (0.946)

0.64 (0.121)

Cu, ppb

1.12 (0.487)

1.00 (na)

0.82 (0.371)

1.48 (0.080)

1.15 (0.679)

0.97 (0.909)

K, ppm

1.21 (0.198)

0.98 (0.637)

1.11 (0.640)

1.51 (0.095)

0.87 (0.634)

0.86 (0.599)

Mg, ppm

0.87 (0.409)

1.11 (0.027)

0.96 (0.847)

2.30 (0.018)

1.56 (0.239)

1.05 (0.771)

Na, ppm

1.20 (0.204)

1.00 (0.999)

1.01 (0.969)

1.93 (0.016)

0.91 (0.740)

1.14 (0.584)

Se, ppb

1.02 (0.881)

1.01 (0.792)

0.91 (0.653)

1.76 (0.025)

1.18 (0.570)

0.76 (0.379)

Zn, ppb

1.50 (0.033)

1.00 (0.997)

0.81 (0.357)

2.11 (0.022)

1.27 (0.483)

0.91 (0.751)

Non-essential metals

Ag, ppb

0.89 (0.500)

0.98 (0.534)

1.05 (0.771)

1.27 (0.273)

1.27 (0.273)

1.33 (0.094)

Al, ppb

1.64 (0.003)

1.03 (0.536)

0.92 (0.670)

1.31 (0.331)

1.31 (0.510)

1.33 (0.223)

As, ppb

1.11 (0.516)

1.01 (0.794)

1.05 (0.820)

1.49 (0.041)

1.18 (0.614)

1.33 (0.344)

Ba, ppb

1.20 (0.300)

1.14 (0.004)

0.80 (0.262)

1.19 (0.503)

1.30 (0.565)

0.69 (0.191)

Be, ppb

0.74 (0.091)

1.06 (0.209)

0.95 (0.775)

1.21 (0.270)

0.85 (0.653)

1.15 (0.579)

Cd, ppb

1.45 (0.084)

0.99 (0.874)

1.07 (0.760)

1.70 (< 0.001)

1.15 (0.702)

1.05 (0.856)

Co, ppb

1.07 (0.638)

0.99 (0.892)

1.03 (0.888)

2.06 (0.003)

0.76 (0.208)

0.95 (0.830)

Cr, ppb

1.21 (0.302)

1.04 (0.323)

0.78 (0.171)

1.02 (0.938)

0.74 (0.379)

0.75 (0.239)

Fe, ppb

1.22 (0.202)

1.05 (0.238)

0.87 (0.511)

1.42 (0.080)

1.05 (0.936)

0.89 (0.623)

Li, ppb

0.92 (0.559)

1.01 (0.853)

1.09 (0.672)

1.82 (0.010)

0.85 (0.467)

1.00 (0.998)

Mn, ppb

1.59 (< 0.001)

1.02 (0.585)

0.99 (0.942)

1.15 (0.441)

1.33 (0.258)

1.17 (0.331)

Mo, ppb

1.32 (0.129)

0.96 (0.315)

1.04 (0.856)

1.86 (0.016)

1.07 (0.796)

0.89 (0.655)

Ni, ppb

1.28 (0.090)

1.00 (na)

0.98 (0.942)

2.14 (0.014)

1.06 (0.837)

1.06 (0.809)

Pb, ppb

1.28 (0.087)

1.06 (0.147)

0.86 (0.387)

1.19 (0.315)

1.19 (0.315)

0.99 (0.953)

Sr, ppb

1.01 (0.972)

1.10 (0.029)

0.95 (0.813)

2.69 (0.009)

1.18 (0.553)

0.92 (0.758)

Tl, ppb

1.48 (0.013)

0.96 (0.394)

1.03 (0.874)

1.64 (0.191)

1.11 (0.718)

1.26 (0.390)

V, ppb

1.16 (0.292)

1.00 (na)

0.97 (0.842)

1.71 (0.017)

0.98 (0.961)

1.04 (0.826)

U, ppb

1.40 (0.009)

0.99 (0.821)

1.04 (0.808)

0.96 (0.839)

0.96 (0.839)

0.96 (0.849)

Covariates in the model

Maternal age, parity, newborn gender

Maternal age, parity, newborn gender, preterm birth

  1. 1The table presents a relative risk (RR) reflecting a risk of a health outcome as a function of metals concentrations
  2. 2na - not available based on the current analysis