Associations between trunk-to-peripheral fat ratio and cardiometabolic risk factors in elderly Japanese men: baseline data from the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) study

Kouda, Katsuyasu; Fujita, Yuki; Ohara, Kumiko; Tachiki, Takahiro; Tamaki, Junko; Yura, Akiko; Moon, Jong-Seong; Kajita, Etsuko; Uenishi, Kazuhiro; Iki, Masayuki

doi:10.1186/s12199-021-00959-9

Environmental Health and Preventive Medicine

Table 5 Associations between TAR/TLR and cardiometabolic variables after adjusting for potential confounders according to the type of medication

From: Associations between trunk-to-peripheral fat ratio and cardiometabolic risk factors in elderly Japanese men: baseline data from the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) study

	Medication for
	Hypertension				Dyslipidemia				Diabetes
	User, N = 256		Non-user, N = 341		User, N = 167		Non-user, N = 430		User, N = 92		Non-user, N = 505
	Beta	P	Beta	P	Beta	P	Beta	P	Beta	P	Beta	P
TAR
Systolic blood pressure	− 0.01	ns	0.05	ns	0.17	0.04	− 0.02	ns	0.11	ns	0.04	ns
Diastolic blood pressure	− 0.01	ns	0.00	ns	0.13	ns	− 0.04	ns	0.00	ns	0.04	ns
LDL cholesterol	0.01	ns	0.18	< 0.01	0.04	ns	0.13	0.01	0.10	ns	0.12	0.02
HDL cholesterol	− 0.24	< 0.01	− 0.25	< 0.01	− 0.17	0.03	− 0.26	< 0.01	− 0.31	< 0.01	− 0.23	< 0.01
Total cholesterol	− 0.04	ns	0.11	ns	0.05	ns	0.03	ns	0.04	ns	0.04	ns
Triglyceride	0.28	< 0.01	0.34	< 0.01	0.34	< 0.01	0.29	< 0.01	0.39	< 0.01	0.29	< 0.01
Hemoglobin A1c	0.17	< 0.01	0.17	< 0.01	0.12	ns	0.17	< 0.01	0.03	ns	0.16	< 0.01
Fasting serum insulin	0.24	< 0.01	0.24	< 0.01	0.26	< 0.01	0.24	< 0.01	0.21	ns	0.21	< 0.01
Fasting plasma glucose	0.16	0.02	0.16	0.01	0.17	0.04	0.15	< 0.01	0.04	ns	0.14	< 0.01
HOMA-IR	0.24	< 0.01	0.25	< 0.01	0.27	< 0.01	0.24	< 0.01	0.18	ns	0.22	< 0.01
TLR
Systolic blood pressure	− 0.01	ns	0.06	ns	0.18	0.02	− 0.02	ns	0.11	ns	0.04	ns
Diastolic blood pressure	− 0.02	ns	0.00	ns	0.13	ns	− 0.05	ns	− 0.01	ns	0.03	ns
LDL cholesterol	0.00	ns	0.19	< 0.01	0.02	ns	0.13	0.01	0.10	ns	0.11	0.03
HDL cholesterol	− 0.23	< 0.01	− 0.24	< 0.01	− 0.17	0.03	− 0.25	< 0.01	− 0.32	< 0.01	− 0.22	< 0.01
Total cholesterol	− 0.05	ns	0.13	0.04	0.02	ns	0.05	ns	0.03	ns	0.05	ns
Triglyceride	0.27	< 0.01	0.35	< 0.01	0.33	< 0.01	0.30	< 0.01	0.40	< 0.01	0.29	< 0.01
Hemoglobin A1c	0.17	< 0.01	0.17	< 0.01	0.14	ns	0.17	< 0.01	0.04	ns	0.16	< 0.01
Fasting serum insulin	0.26	< 0.01	0.22	< 0.01	0.28	< 0.01	0.23	< 0.01	0.21	0.05	0.21	< 0.01
Fasting plasma glucose	0.17	< 0.01	0.14	0.02	0.18	0.03	0.15	< 0.01	0.04	ns	0.14	< 0.01
HOMA-IR	0.26	< 0.01	0.23	< 0.01	0.28	< 0.01	0.24	< 0.01	0.19	ns	0.22	< 0.01

Biochemical marker values were logarithmically converted and then statistically analyzed
Multiple regression analysis was used after adjusting for age, height, MET-minutes/week, current smoker, alcohol intake,
energy intake, NaCl intake, and whole-body fat
Beta represents the standard coefficient
P < 0.05 was considered statistically significant
MET-minutes/week was calculated using the International Physical Activity Questionnaire
N, number; ns, not significant; TAR, trunk-to-appendicular fat ratio; TLR, trunk-to-leg fat ratio; HDL, high-density lipoprotein; LDL, low-density lipoprotein; HOMA-IR, homeostasis model assessment-insulin resistance; MET, metabolic equivalent of task

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