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Table 1 Analytical methods for detecting glyphosate in human urine samples

From: Optimization and validation of a highly sensitive method for determining glyphosate in human urine by solid-phase extraction and liquid chromatography with tandem mass spectrometry: a methodological study

References

Sample preparation

Instrument for separation analysis

Limit of detection (μg/L)

Acquavella et al. [15]

Solid-phase extraction, derivatization

HPLC

1

Biagini et al. [16]

Derivatization

FCMIA

0.9

Curwin et al. [17]

Derivatization

FCMIA

0.9

Jayasumana et al. [12]

 

ELISA

0.6

Jensen et al. [18]

Dilution of urine

LC-MS/MS (ESI)

0.023

Connolly et al. [14]

Solid-phase extraction

LC-MS/MS (ESI)

0.5

Conrad et al. [10]

Derivatization

GC-MS/MS (NCI)

0.1 (LLOQ)

  1. HPLC high-performance liquid chromatography, FCMIA fluorescence covalent microbead immunosorbent assay, ELISA enzyme-linked immunosorbent assay, LC liquid chromatography, GC gas chromatography, MS mass spectrometry, ESI electrospray ionization, NCI negative chemical ionization, LLOQ lower limit of quantification