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Table 3 Overall and subgroup meta-analysis of the association between AhR polymorphisms and cancer risk

From: Lack of association between multiple polymorphisms in aryl hydrocarbon receptor (AhR) gene and cancer susceptibility

Polymorphismmodel

Population

No. of studies

Test of association

Test of heterogeneity

(Cases/Controls)

OR

95%CI

PZ value

Model

PQ value

I2

rs2066853 G>A

AA+GA vs. GGa

Overall

17 (9496/9977)

1.008

0.898–1.131

0.899

R

< 0.0001

66.662

Asians

9 (3851/3983)

1.093

0.885–1.351

0.408

R

< 0.0001

78.872

Chinese

5 (2065/2289)

1.168

0.846–1.614

0.345

R

< 0.0001

81.794

Caucasians

3 (2102/2423)

1.001

0.869–1.154

0.985

F

0.383

0

lung cancer

6 (2046/2245)

0.904

0.721–1.134

0.384

R

0.021

62.421

breast cancer

4 (3031/3057)

1.014

0.791–1.300

0.912

R

0.004

77.604

AA vs. GA+GGb

Overall

17 (9496/9977)

0.994

0.860–1.149

0.937

R

0.099

32.183

Asians

9 (3851/3983)

0.955

0.834–1.093

0.503

F

0.133

35.627

Chinese

5 (2065/2289)

1.018

0.848–1.222

0.849

F

0.143

41.746

Caucasians

3 (2102/2423)

1.536

0.991–2.382

0.055

F

0.485

0

lung cancer

6 (2046/2245)

0.899

0.736–1.098

0.298

F

0.158

37.238

breast cancer

4 (3031/3057)

0.944

0.804–1.109

0.482

F

0.459

0

AA vs. GGc

Overall

17 (9496/9977)

1.038

0.868–1.242

0.679

R

0.011

49.276

Asians

9 (3851/3983)

1.024

0.797–1.315

0.856

R

0.007

62.256

Chinese

5 (2065/2289)

1.157

0.791–1.694

0.452

R

0.014

67.815

Caucasians

3 (2102/2423)

1.522

0.981–2.361

0.061

F

0.479

0

lung cancer

6 (2046/2245)

0.903

0.728–1.120

0.351

F

0.102

45.628

breast cancer

4 (3031/3057)

0.948

0.801–1.122

0.534

F

0.122

48.2

A vs. Gd

Overall

17 (9496/9977)

0.995

0.911–1.086

0.906

R

< 0.0001

63.137

Asians

9 (3851/3983)

1.031

0.888–1.198

0.686

R

< 0.0001

76.933

Chinese

5 (2065/2289)

1.105

0.883–1.383

0.381

R

0.001

79.311

Caucasians

3 (2102/2423)

1.039

0.914–1.181

0.557

F

0.396

0

lung cancer

6 (2046/2245)

0.904

0.769–1.063

0.221

R

0.043

56.320

breast cancer

4 (3031/3057)

0.993

0.831–1.185

0.936

R

0.009

73.976

rs7796976 G>A

AA+GA vs. GGa

Overall

3 (2489/2415)

0.928

0.829–1.040

0.198

F

0.458

0.000

AA vs. GA+GGb

Overall

3 (2489/2415)

0.932

0.759–1.145

0.504

F

0.738

0.000

AA vs. GGc

Overall

3 (2489/2415)

0.897

0.725–1.110

0.319

F

0.557

0.000

A vs. Gd

Overall

3 (2489/2415)

0.942

0.862–1.030

0.191

F

0.447

0.000

rs2074113 C>A

AA+CA vs. CCa

Overall

3

1.021

0.895–1.165

0.755

F

0.613

0.000

AA vs. CA+CCb

Overall

3

0.895

0.706–1.135

0.361

F

0.275

22.596

AA vs. CCc

Overall

3

0.950

0.739–1.220

0.686

F

0.377

0.000

A vs. Cd

Overall

3

0.992

0.893–1.102

0.876

F

0.574

0.000

  1. AhR Aryl hydrocarbon receptor, OR Odds ratio, 95%CI 95% confidence interval, F The fixed-effect model, R The random-effect model, PZ value P value for Z test, PQ value P value for Q test
  2. aDominant model
  3. bRecessive model
  4. cCodominant model
  5. dAllelic model