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Table 3 Functional properties of human CD8+ T cell line following long-term exposure to asbestos fibers

From: Effect of asbestos exposure on differentiation and function of cytotoxic T lymphocytes

Parameters

EBT-8-Org

EBT-8-CH5 or/and EBT-8-CH30

Significance

Granzyme B (MFI)

++ or +

+ or ++

N.S.

Perforin+ (%)

++

+

p < 0.01

IFN-γ+ (%)

++ or +

+ or ++

N.S.

Production of IFN-γ

++

+

p < 0.0001

Degranulation (%)

+

+

N.S.

  1. MFI mean fluorescence intensity, N.S. not significant
  2. The human CD8+ T cell line was then cultured in the absence or presence of CH asbestos at low or middle concentrations of 5 or 30 μg/ml for 1 to 2 months, with cell groups being referred to as EBT-8-Org, EBT-8-CH5, and EBT-8-CH30, respectively