Effect of asbestos exposure on differentiation and function of cytotoxic T lymphocytes

Table 2 Functional properties of CD8⁺ lymphocytes in individuals with pleural plaque and patients with malignant mesothelioma

Parameters		HV	PP	MM
CD3⁺CD8⁺ (%)		+	+	+
CD107a⁺ (%)		+	+	+
IFN-γ⁺ (%)		+	+	+
Granzyme B⁺ (%)	Before	+	+	+
	After	+	++	+
	After-Before	+	++	+
Perforin⁺ (%)	Before	++	+++	+++
	After	++	+++	++
	After-Before	++	++	+
CD45RA^- (%)		+	++	++
CD3⁺CD8⁺ (cell number)		++	+	+

HV healthy volunteers, PP asbestos-exposed individuals with pleural plaque, MM asbestos-exposed patients with malignant mesothelioma, Before the percentage of granzyme B⁺ cells in fresh CD8⁺ lymphocytes, After the percentage of granzyme B⁺ cells in stimulated CD8⁺ lymphocytes, After-Before the percentage of granzyme B⁺ or perforin⁺ cells in fresh CD8⁺ lymphocytes was subtracted from the percentage of granzyme B⁺ or perforin⁺ cells in stimulated cells

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