Table 6 Assessment of markers of liver injuries in rat
Treatment groups | Liver injuries | |||||
|---|---|---|---|---|---|---|
Steatosis | Leukocyte infiltration | Fatty degeneration | Perivascular & lobular necrosis | Cellular hypertrophy | Sinusoidal obstruction | |
Control | +/− | +/− | +/− | +/− | +/− | +/− |
CCl4 (1 ml/kg bw) | +++ | +++ | +++ | +++ | +++ | +++ |
CCl4 + Silymarin (200 mg/kg bw) | + | + | ++/− | + | + | + |
CCl4 + PUM (150 mg/kg bw) | ++/− | ++ | ++ | ++/− | ++ | ++/− |
CCl4 + PUM (300 mg/kg bw) | + | ++/− | ++/− | + | ++/− | + |
PUM (150 mg/kg bw) | +/− | +/− | +/− | +/− | +/− | +/− |
PUM (300 mg/kg bw) | +/− | +/− | + | +/− | + | +/− |