Pilea umbrosa ameliorate CCl4 induced hepatic injuries by regulating endoplasmic reticulum stress, pro-inflammatory and fibrosis genes in rat

Table 5 Effects of PUM on hepatic biochemical markers of rat

	Protein (μg mg − 1 tissue)	TBARS (nM mg − 1 protein)	Nitrite (nM ml − 1)	H₂O₂ (nM mg − 1 protein)
Control	15.55 ± 0.32^a	36.41 ± 4.58^d	44.40 ± 1.79^d	4.23 ± 0.44^e
CCl₄ (1 ml/kg bw)	11.09 ± 0.33^f	67.16 ± 4.74^a	66.17 ± 1.72^a	9.29 ± 1.22^a
CCl₄ + Silymarin (200 mg/kg bw)	14.37 ± 0.22^c	46.43 ± 2.54^c	44.85 ± 2.44^cd	5.62 ± 0.20^d
CCl₄ + PUM (150 mg/kg bw)	13.37 ± 0.34^e	52.80 ± 3.35^b	54.77 ± 6.19^b	8.15 ± 0.05^b
CCl₄ + PUM (300 mg/kg bw)	14.18 ± 0.35^d	49.54 ± 2.55^b	52.86 ± 2.59^bc	6.65 ± 0.32^c
PUM (150 mg/kg bw)	14.88 ± 0.36^b	38.72 ± 5.21^d	42.18 ± 0.96^d	5.94 ± 0.37^cd
PUM (300 mg/kg bw)	15.27 ± 0.29^ab	41.01 ± 4.00^d	44.85 ± 1.35^cd	5.35 ± 0.65^d

Mean ± SD (n = 6 male rats); Means not sharing common superscript (^a-f) indicate significance difference at P > 0.05. PUM Methanol extract of Pilea umbrosa, TBARS Thiobarbituric acid reactive substances

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