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Table 4 Effect of PUM on serum biochemical markers of liver

From: Pilea umbrosa ameliorate CCl4 induced hepatic injuries by regulating endoplasmic reticulum stress, pro-inflammatory and fibrosis genes in rat

 

ALT (u/l)

AST (u/l)

ALP (u/l)

Albumin

(mg/dl)

Bilirubin

(mg/dl)

Control

37.80 ± 1.93e

68.46 ± 0.75e

60.20 ± 3.02e

4.61 ± 0.16a

0.59 ± 0.03e

CCl4 (1 ml/kg bw)

125.70 ± 1.57a

147.30 ± 0.74a

168.40 ± 2.42a

2.27 ± 0.14d

1.71 ± 0.04a

CCl4 + Silymarin (200 mg/kg bw)

47.33 ± 1.24d

76.76 ± 0.89cd

85.40 ± 1.82c

3.80 ± 0.16bc

0.79 ± 0.05cd

CCl4 + PUM (150 mg/kg bw)

89.67 ± 0.94b

122.66 ± 1.24b

95.76 ± 1.35b

2.84 ± 0.07d

1.04 ± 0.08b

CCl4 + PUM (300 mg/kg bw)

52.17 ± 0.84c

80.36 ± 2.08c

88.56 ± 2.15bc

3.61 ± 0.06c

0.84 ± 0.04c

PUM (150 mg/kg bw)

46.47 ± 1.30d

72.46 ± 0.33de

75.20 ± 2.33d

4.26 ± 0.26ab

0.71 ± 0.02cde

PUM (300 mg/kg bw)

32.77 ± 1.15f

74.53 ± 1.90d

65.11 ± 0.99e

4.44 ± 0.21a

0.63 ± 0.06de

  1. Mean ± SD (n = 6 male rats); Means not sharing common superscript (a-f) indicate significance difference at P > 0.05. PUM Methanol extract of Pilea umbrosa, AST Aspartate transaminase, ALT Alanine transaminase, ALP Alkaline phosphatase