Pilea umbrosa ameliorate CCl4 induced hepatic injuries by regulating endoplasmic reticulum stress, pro-inflammatory and fibrosis genes in rat

Table 3 Effects of PUM on liver and body weight of rat

Treatment groups	Initial body weight (g)	Final body weight (g))	% increase in body weight	Absolute liver weight (g)	Relative liver weight (mg/g of body weight)
Control	122.70 ± 2.05	219.33 ± 3.39	79.08 ± 0.52^c	8.16 ± 0.23^cd	37.18 ± 0.78^cd
CCl₄ (1 ml/kg bw)	126.33 ± 2.62	177 ± 3.56	40.10 ± 0.79^f	9.12 ± 0.08^a	51.56 ± 1.02^a
CCl₄ + Silymarin (200 mg/kg bw)	119.30 ± 0.94	187.67 ± 2.05	57.25 ± 0.76^e	8.37 ± 0.09^bc	44.59 ± 0.97^b
CCl₄ + PUM (150 mg/kg bw)	121.70 ± 2.36	193 ± 3.55	58.63 ± 0.38^e	8.70 ± 0.08^ab	45.09 ± 0.97^b
CCl₄ + PUM (300 mg/kg bw)	123.25 ± 2.05	215.25 ± 3.26	74.64 ± 0.25^d	8.40 ± 0.12^bc	39.02 ± 0.57^c
PUM (150 mg/kg bw)	122.50 ± 2.50	224 ± 4	82.86 ± 0.46^b	8.38 ± 0.14^bc	37.39 ± 0.65^c
PUM (300 mg/kg bw)	120 ± 0	226.50 ± 1.11	88.75 ± 0.93^a	7.90 ± 0.18^d	34.87 ± 0.82^d

Mean ± SD (n = 6 male rats); Means not sharing common superscript (^a-f) indicate significance difference at P > 0.05. PUM Methanol extract of Pilea umbrosa

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