Association between surgical procedures under general anesthesia in infancy and developmental outcomes at 1 year: the Japan Environment and Children’s Study

Table 3 Number of delayed infants for each J-ASQ-3 domain, according to the number of surgery

J-ASQ-3	Surgery under general anesthesia				p value for trend^a
J-ASQ-3	None (n = 63,234)	1 time (n = 746)	2 times (n = 90)	≥ 3 times (n = 71)	p value for trend^a
Communication	4373 (6.9%)	64 (8.6%)	9 (10.0%)	16 (22.5%)	< 0.001
Gross motor	8695 (13.8%)	159 (21.3%)	36 (40.0%)	34 (47.9%)	< 0.001
Fine motor	6167 (9.8%)	94 (12.6%)	23 (25.6%)	19 (26.8%)	< 0.001
Problem solving	9628 (15.2%)	145 (19.4%)	27 (30.0%)	25 (35.2%)	< 0.001
Personal–social	10,558 (16.7%)	151 (20.2%)	32 (35.6%)	27 (38.0%)	< 0.001

Data are n (%) unless otherwise specified. The cutoff scores from the original ASQ-3 were used [20]
J-ASQ-3 Japanese translation of the Ages and Stages Questionnaire-Third Edition
^aCochran–Armitage test

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