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Table 4 Results of Bayesian multivariable logistic regression for allergic features associated with number of initial inactivated vaccines for complete cases (RQ2)

From: Cumulative inactivated vaccine exposure and allergy development among children: a birth cohort from Japan

 

Variable: number of vaccines

aOR_P25

aOR_P50

aOR_P75

95% CrI_lower

95% CrI_upper

Pr (aOR > 1.0)

Pr (aOR > 1.5)

Pr (aOR > 2.0)

Allergic disease

2 vs. 1

0.975

0.993

1.011

0.941

1.047

0.397

< 0.0001

< 0.0001

3 vs. 1

1.012

1.045

1.077

0.956

1.141

0.825

< 0.0001

< 0.0001

4 or 5 vs. 1

1.063

1.097

1.133

1.003

1.201

0.978

< 0.0001

< 0.0001

Atopic dermatitis

2 vs. 1

0.909

0.947

0.989

0.841

1.067

0.194

< 0.0001

< 0.0001

3 vs. 1

1.002

1.073

1.147

0.885

1.300

0.758

0.001

< 0.0001

4 or 5 vs. 1

1.023

1.095

1.170

0.810

1.330

0.815

0.001

< 0.0001

Food allergy

2 vs. 1

0.939

0.959

0.980

0.899

1.020

0.090

< 0.0001

< 0.0001

3 vs. 1

0.930

0.965

1.002

0.864

1.074

0.263

< 0.0001

< 0.0001

4 or 5 vs. 1

0.927

0.963

1.000

0.862

1.076

0.250

< 0.0001

< 0.0001

Asthma

2 vs. 1

1.133

1.202

1.275

1.015

1.434

0.982

0.007

< 0.0001

3 vs. 1

1.279

1.392

1.518

1.072

1.799

0.992

0.281

0.004

4 or 5 vs. 1

1.413

1.538

1.676

1.198

1.967

1.000

0.581

0.019

Wheeze

2 vs. 1

0.969

0.990

1.012

0.929

1.056

0.377

< 0.0001

< 0.0001

3 vs. 1

1.195

1.237

1.281

1.116

1.374

1.000

< 0.0001

< 0.0001

4 or 5 vs. 1

1.089

1.129

1.171

1.016

1.254

0.987

< 0.0001

< 0.0001

Eczema

2 vs. 1

0.985

1.007

1.029

0.945

1.072

0.578

< 0.0001

< 0.0001

3 vs. 1

1.072

1.112

1.153

0.999

1.234

0.974

< 0.0001

< 0.0001

4 or 5 vs. 1

1.103

1.144

1.187

1.027

1.269

0.992

< 0.0001

< 0.0001

  1. Parameters: iterations = 11000, chains = 4, thinning = 4, warm-ups = 1000.
  2. aOR adjusted odds ratio, CrI credible interval, Pr probability, P25 25th percentile, P50 50th percentile, P75 75th percentile
  3. Results of 95% CrI > 1.0 and probability > 0.975 are shown in bold
  4. aORs were estimated with potential confounders including maternal age, primiparity, maternal allergy history, smoking during pregnancy, pet ownership during pregnancy, sex of child, feeding at 6 months, nursery school attendance, maternal education level, annual family income and place of recruitment