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Table 3 Results of univariable and multivariable logistic regression for allergic features associated with number of initial inactivated vaccines received, in the JECS birth cohort (RQ2)

From: Cumulative inactivated vaccine exposure and allergy development among children: a birth cohort from Japan

Allergy features at 1 year old

Number of inactivated vaccines

Univariable

Multivariable for complete cases

OR

Lower 95% CI

Upper 95% CI

p value

aOR

Lower 95% CI

Upper 95% CI

p value

Allergic disease

2 vs. 1

1.012

0.953

1.072

0.932

0.993

0.932

1.059

0.710

3 vs. 1

1.031

0.934

1.137

0.932

1.044

0.938

1.162

0.686

4 or 5 vs. 1

1.075

0.973

1.188

0.263

1.098

0.985

1.223

0.125

Atopic dermatitis

2 vs. 1

0.957

0.837

1.093

0.683

0.947

0.820

1.094

1.000

3 vs. 1

1.116

0.900

1.384

0.683

1.076

0.851

1.360

1.000

4 or 5 vs. 1

1.113

0.893

1.386

0.683

1.095

0.866

1.385

1.000

Food allergy

2 vs. 1

0.939

0.875

1.009

0.075

0.959

0.888

1.035

0.579

3 vs. 1

0.886

0.784

1.002

0.059

0.965

0.847

1.101

1.000

4 or 5 vs. 1

0.914

0.807

1.036

0.089

0.963

0.842

1.101

1.000

Asthma

2 vs. 1

1.278

1.063

1.538

0.002

1.201

0.981

1.470

0.034

3 vs. 1

1.662

1.268

2.179

<  0.0001

1.395

1.028

1.893

0.021

4 or 5 vs. 1

1.800

1.375

2.356

<  0.0001

1.544

1.149

2.075

0.002

Wheeze

2 vs. 1

1.035

0.966

1.109

0.240

0.990

0.916

1.069

0.752

3 vs. 1

1.286

1.152

1.435

<  0.0001

1.238

1.094

1.401

< 0.0001

4 or 5 vs. 1

1.248

1.114

1.397

<  0.0001

1.130

0.995

1.283

0.046

Eczema

2 vs. 1

1.021

0.952

1.096

0.485

1.006

0.932

1.086

0.851

3 vs. 1

1.086

0.966

1.220

0.191

1.113

0.980

1.261

0.095

4 or 5 vs. 1

1.116

0.992

1.257

0.084

1.144

1.007

1.299

0.038

  1. OR odds ratio, aOR adjusted odds ratio, CI confidence interval
  2. aOR and 95% CIs were estimated with potential confounders including maternal age, primiparity, maternal allergy history, smoking during pregnancy, pet ownership during pregnancy, sex of child, feeding at 6 months, nursery school attendance, maternal education level, annual family income and place of recruitment. The adjusted p values were calculated by Holm method. Results of p value < 0.05 are shown in bold