Cumulative inactivated vaccine exposure and allergy development among children: a birth cohort from Japan

Table 1 Results of univariable and multivariable logistic regression for allergic features associated with initial inactivated vaccine compared with initial live vaccine only, in the JECS birth cohort (RQ1)

Allergy features at 1 year old	Univariable				Multivariable for complete cases				Multivariable for multiple imputed data
Allergy features at 1 year old	OR	Lower 95% CI	Upper 95% CI	p value	aOR	Lower 95% CI	Upper 95% CI	p value	aOR	Lower 95% CI	Upper 95% CI	p value
Allergic disease	0.984	0.935	1.035	0.521	0.994	0.940	1.051	0.832	0.985	0.935	1.037	0.553
Atopic dermatitis	0.909	0.813	1.016	0.093	0.943	0.834	1.065	0.341	0.914	0.816	1.023	0.118
Food allergy	1.008	0.947	1.074	0.805	1.013	0.946	1.084	0.720	1.011	0.948	1.078	0.736
Asthma	1.027	0.885	1.192	0.724	0.989	0.840	1.164	0.894	1.033	0.887	1.203	0.679
Wheeze	1.001	0.944	1.062	0.963	0.980	0.917	1.047	0.550	0.991	0.932	1.054	0.776
Eczema	0.978	0.921	1.039	0.474	1.009	0.944	1.078	0.797	0.992	0.933	1.054	0.785

OR odds ratio, aOR adjusted odds ratio, CI confidence interval
aOR and 95% CIs were estimated with potential confounders including maternal age, primiparity, maternal allergy history, smoking during pregnancy, pet ownership during pregnancy, sex of child, feeding at 6 months, nursery school attendance, maternal education level, annual family income and place of recruitment

ISSN: 1347-4715