Fig. 2
From: Multidisciplinary approach to assess the toxicities of arsenic and barium in drinking water
Biochemical analyses of cutaneous and oncogenic toxicities of arsenic and barium. Arsenic and barium may promote the development of hyperpigmented skin and malignant transformation and progression via activation of various intracellular signal transduction molecules. EDNRB endothelin receptor B, MITF microphthalmia-associated transcription factor, PlGF placental growth factor, VEGFR1 vascular endothelial growth factor receptor1, MEK mitogen-activated protein kinase, ERK extracellular signal–regulated kinase, MMPs matrix metalloproteinase, FAK focal adhesion kinase