From: The relationship between metabolic syndrome and the incidence of colorectal cancer
Characteristics | Category | HR (95% CI) | |||||
---|---|---|---|---|---|---|---|
Non–Adjusted | aModel 1 | bModel 2 | cModel 3 | dModel 4 | eModel 5 | ||
Metabolic syndrome (MetS) stage | Normal | Ref. | Ref. | Ref. | Ref. | Ref | Ref. |
Pre-MetS | 1.39 (1.32 1.46) | 1.14 (1.08 1.20) | 1.13 (1.07 1.19) | 1.12 (1.05 1.20) | 1.09 (1.01 1.16) | 1.09 (1.02 1.17) | |
MetS | 2.15 (2.01 2.30) | 1.50 (1.40 1.61) | 1.49 (1.39 1.59) | 1.52 (1.40 1.66) | 1.39 (1.26 1.52) | 1.39 (1.26 1.53) | |
Age | 30-39 | Ref. | Ref. | Ref. | Ref. | Ref. | |
40-49 | 1.74 (1.28 2.36) | 1.77 (1.30 2.41) | 1.66 (1.15 2.40) | 1.62 (1.12 2.34) | 1.64 (1.13 2.37) | ||
50-59 | 4.03 (2.99 5.43) | 4.19 (3.10 5.66) | 3.89 (2.71 5.59) | 3.71 (2.58 5.33) | 3.76 (2.62 5.40) | ||
60 | 6.38 (4.74 8.60) | 6.74 (4.99 9.12) | 6.37 (4.44 9.15) | 5.97 (4.15 8.60) | 6.04 (4.20 8.68) | ||
Smoking | Non-smoker | Ref. | Ref. | Ref. | Ref. | ||
Ex-smoker | 1.25 (1.06 1.49) | 1.32 (1.08 1.60) | 1.31 (1.07 1.59) | 1.32 (1.08 1.60) | |||
Smoker | 1.25 (1.10 1.41) | 1.23 (1.06 1.43) | 1.23 (1.06 1.43) | 1.23 (1.06 1.43) | |||
Alcohol consumption | No drink | Ref. | Ref. | Ref. | Ref. | ||
2–3/per month | 1.11 (1.05 1.18) | 1.12 (1.05 1.21) | 1.12 (1.05 1.21) | 1.12 (1.05 1.20) | |||
1–4/per week | 1.20 (1.05 1.36) | 1.13 (0.96 1.33) | 1.13 (0.96 1.33) | 1.13 (0.96 1.33) | |||
5/per week | 0.99 (0.79 1.24) | 1.07 (0.82 1.40) | 1.07 (0.82 1.40) | 1.07 (0.82 1.40) | |||
Physical exercise, per week | No exercise | Ref. | Ref. | Ref. | Ref. | ||
1–4/per week | 1.04 (0.98 1.10) | 1.03 (0.96 1.11) | 1.03 (0.96 1.11) | 1.03 (0.96 1.12) | |||
5/per week | 0.96 (0.91 1.01) | 0.96 (0.89 1.02) | 0.95 (0.89 1.02) | 0.96 (0.90 1.02) | |||
FHx of cancer | No | Ref. | Ref. | Ref. | |||
Yes | 1.09 (1.01 1.17) | 1.09 (1.01 1.17) | 1.09 (1.01 1.17) | ||||
Hemoglobin (g/dL) | > 10 | Ref | Ref | ||||
8–10 | 1.15 (0.94 1.40) | 1.15 (0.94 1.40) | |||||
< 8 | 0.91 (0.55 1.51) | 0.90 (0.54 1.50) | |||||
Serum creatinine (mg/dL) | ≤ 1.5 | Ref | Ref | ||||
> 1.5 | 0.92 (0.75 1.13) | 0.92 (0.75 1.13) | |||||
eTotal cholesterol(mg/dL) | 1.03 (1.01 1.04) | 1.03 (1.01 1.04) | |||||
fALT (IU/L) | 1.00 (0.99 1.02) | 1.00 (0.99 1.02) | |||||
Height (cm) | < 154 | Ref | |||||
154–156 | 1.05 (0.97 1.13) | ||||||
157–160 | 0.91 (0.88 1.03) | ||||||
≥161 | 0.94 (0.85 1.03) | ||||||
Weight (kg) | < 52 | Ref | |||||
52–55 | 1.03 (0.94 1.12) | ||||||
56–61 | 1.09 (1.01 1.19) | ||||||
≥ 62 | 1.18 (1.08 1.29) | ||||||
eBMI (kg/m2) | < 18.5 | 1.01 (0.84 1.22) | |||||
18.5–22.9 | Ref | ||||||
23.0–24.9 | 1.09 (1.01 1.17) | ||||||
25.0–29.9 | 1.13 (1.05 1.22) | ||||||
≥ 30.0 | 1.20 (1.03 1.39) |