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Table 2 Cumulative incidence rate and incidence density of colorectal cancer according to the progression of metabolic syndrome in women

From: The relationship between metabolic syndrome and the incidence of colorectal cancer

Characteristics Category No. of study population No. of colorectal cancer Cumulative incidence rate (per 1000) Incidence density (per 10,000 person-years)
Normal Pre-MetS MetS Total Normal Pre-MetS MetS Total Normal Pre-MetS MetS p value Total p value Normal Pre-MetS MetS p value Total p value
Total 1,016,532 1,320,685 332,269 2,669,486 2119 3827 1493 7439 2.1 2.9 4.5   2.8   2.2 3.1 4.8   3.0  
Age 30–39 44,462 24,310 1909 70,681 29 14 1 44 0.7 0.6 0.5 < 0.001 0.6 < 0.001 0.7 0.6 0.6 < 0.001 0.7 < 0.001
40–49 355,151 277,454 33,864 666,469 363 323 46 732 1.0 1.2 1.4 < 0.001 1.1 1.1 1.3 1.5 < 0.001 1.2
50–59 424,813 555,494 114,030 1,094,337 1030 1464 416 2910 2.4 2.6 3.6 < 0.001 2.7 2.6 2.8 3.9 < 0.001 2.9
60–69 192,106 463,427 182,466 837,999 697 2026 1030 3753 3.6 4.4 5.6 < 0.001 4.5 3.9 4.7 6.0 < 0.001 4.8
Smoking Non-smoker 958,586 1,249,613 312,149 2,520,348 1,997 3581 1393 6971 2.1 2.9 4.5 < 0.001 2.8 < 0.001 2.2 3.1 4.8 < 0.001 3.0 < 0.001
Ex-smoker 20,223 21,067 5,102 46,392 45 69 23 137 2.2 3.3 4.5 < 0.001 3.0 2.4 3.5 4.8 < 0.001 3.2
Smoker 31,594 42,661 13,015 87,270 71 155 68 294 2.2 3.6 5.2 < 0.001 3.4 2.4 3.9 5.6 < 0.001 3.6
Alcohol consumption No drink 695,610 956,081 255,189 1,906,880 1,460 2792 1167 5419 2.1 2.9 4.6 < 0.001 2.8 < 0.001 2.3 3.1 4.9 < 0.001 3.0 < 0.001
2–3/per month 267,878 291,847 58,767 618,492 549 816 245 1610 2.0 2.8 4.2 < 0.001 2.6 2.2 3.0 4.5 < 0.001 2.8
1–4/per week 30,509 41,508 9,949 81,966 76 132 42 250 2.5 3.2 4.2 < 0.001 3.1 2.7 3.4 4.5 < 0.001 3.3
5/per week 8,547 13,865 3,936 26,348 18 42 17 77 2.1 3.0 4.3 < 0.001 2.9 2.3 3.3 4.6 < 0.001 3.1
Physical exercise,
per week
No exercise 529,972 692,901 179,742 1,402,615 1092 1998 781 3871 2.1 2.9 4.3 < 0.001 2.8 < 0.001 2.2 3.1 4.7 < 0.001 3.0 < 0.001
1–4/per week 191,856 241,698 59,221 492,775 412 721 270 1403 2.1 3.0 4.6 < 0.001 2.8 2.3 3.2 4.9 < 0.001 3.1
5/per week 288,778 379,098 91,511 759,387 611 1092 432 2135 2.1 2.9 4.7 < 0.001 2.8 2.3 3.1 5.1 < 0.001 3.0
FHx of cancer No 554,083 725,060 189,415 1,468,558 1,103 2069 854 4026 2.0 2.9 4.5 < 0.001 2.7 < 0.001 2.1 3.1 4.8 < 0.001 2.9 < 0.001
Yes 121,122 147,564 34,493 303,179 297 441 174 912 2.5 3.0 5.0 < 0.001 3.0 2.6 3.2 5.4 < 0.001 3.2
Height
(cm)
<154 264,445 431,540 124,997 820,982 628 1419 613 2657 2.4 1.5 4.9 < 0.001 3.2 < 0.001 2.5 3.5 5.2 < 0.001 3.5 < 0.001
154–156 210,014 285,243 73,169 568,426 458 873 360 1691 2.7 4.0 5.7 < 0.001 4.1 2.3 3.3 5.3 < 0.001 3.2
157–160 285,846 344,154 80,677 710,677 606 946 302 1854 2.1 3.2 4.9 < 0.001 3.3 2.3 2.9 4.0 < 0.001 2.8
≥ 161 256,227 259,748 53,426 569,401 427 589 218 1234 1.8 2.6 3.7 < 0.001 2.7 1.8 2.4 4.4 < 0.001 2.3
Weight (kg) < 52 413,406 340,565 29,049 783,020 770 943 121 1834 1.9 2.3 4.2 < 0.001 2.3 < 0.001 2.0 3.0 4.5 < 0.001 2.5 <0.001
52–55 255,743 285,512 38,948 580,203 542 806 174 1522 2.1 1.9 4.5 < 0.001 2.6 2.3 3.0 4.8 < 0.001 2.8
56–61 245,247 375,870 83,951 705,068 578 1127 377 2082 2.4 1.5 4.5 < 0.001 3.0 2.5 3.2 4.8 < 0.001 3.2
≥ 62 102,136 318,738 180,321 601,195 229 951 821 2001 2.2 0.7 4.6 < 0.001 3.3 2.4 3.2 4.9 < 0.001 3.6
BMI (kg/m2) < 18.5 69,872 34,585 1,015 105,472 113 69 4 186 1.6 3.3 3.9 < 0.001 1.8 < 0.001 1.7 2.1 4.3 < 0.001 1.9 < 0.001
18.5–22.9 650,264 583,930 51,625 1,285,819 1,270 1518 203 2991 2.0 2.2 3.9 < 0.001 2.3 2.1 2.8 4.2 < 0.001 2.5
23.0-24.9 199,271 340,173 69,405 608,849 488 1055 309 1852 2.4 1.4 4.5 < 0.001 3.0 2.6 3.3 4.8 < 0.001 3.3
25.0–29.9 95,519 328,761 164,397 588,677 242 1083 770 2095 2.5 0.7 4.7 < 0.001 3.6 2.7 3.5 5.0 < 0.001 3.8
≥ 30.0 1,606 33,236 45,827 80,669 6 102 207 315 3.7 0.2 4.5 < 0.001 3.9 4.0 3.3 4.8 < 0.001 4.2
Total cholesterol (mg/dL) <171 297,122 339,711 56,297 693,130 506 699 218 1423 1.7 1.5 3.9 < 0.001 2.1 < 0.001 1.8 2.2 4.2 < 0.001 2.2 < 0.001
171-192 285,233 308,510 65,401 659,144 528 852 289 1669 1.9 1.7 4.4 < 0.001 2.5 2.0 3.0 4.7 < 0.001 2.7
193–217 250,903 323,283 84,889 659,075 598 1033 382 2013 2.4 1.8 4.5 < 0.001 3.1 2.6 3.4 4.8 < 0.001 3.3
≥ 218 183,274 349,181 125,682 658,137 487 1243 604 2334 2.7 1.4 4.8 < 0.001 3.5 2.8 3.8 5.2 < 0.001 3.8
ALT (IU/L) <13 414,706 370,487 39,262 824,455 752 884 158 1794 1.8 2.0 4.0 < 0.001 2.2 < 0.001 1.9 2.6 4.3 < 0.001 2.3 < 0.001
13–15 219,168 259,979 43,677 522,824 453 754 183 1390 2.1 1.7 4.2 < 0.001 2.7 2.2 3.1 4.5 < 0.001 2.8
16-21 230,941 354,345 88,877 674,163 554 1094 407 2055 2.4 1.6 4.6 < 0.001 3.0 2.6 3.3 4.9 < 0.001 3.3
≥ 22 151,717 335,874 160,453 648,044 360 1095 745 2200 2.4 1.1 4.6 < 0.001 3.4 2.5 3.5 5.0 < 0.001 3.6
Hemoglobin (g/dL) > 10 986,791 1,281,381 325,615 2,593,787 2,060 3742 1464 7266 2.1 1.6 4.5 < 0.001 2.8 < 0.001 2.2 3.1 4.8 < 0.001 3.0 < 0.001
8–10 25,669 32,557 5,620 63,846 51 74 25 150 2.0 1.6 4.4 < 0.001 2.3 2.1 2.4 4.8 < 0.001 2.5
< 8 4,005 6,650 1,005 11,660 8 11 4 23 2.0 1.2 4.0 < 0.001 2.0 2.1 1.8 4.3 < 0.001 2.1
Serum creatinine
(mg/dL)
≤ 1.5 999,732 1,298,976 326,608 2,625,316 2,090 3774 1466 7330 2.1 1.6 4.5 < 0.001 2.8 < 0.001 2.2 3.1 4.8 < 0.001 3.0 < 0.001
> 1.5 16,732 21,632 5,649 44,013 29 53 27 109 1.7 1.3 4.8 < 0.001 2.5 1.9 2.6 5.1 < 0.001 2.7
  1. MetS metabolic syndrome, FHx family history, BMI body mass index, ALT alanine aminotransferase