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Table 1 Cumulative incidence rate and incidence density of colorectal cancer according to the progression of metabolic syndrome in men

From: The relationship between metabolic syndrome and the incidence of colorectal cancer

Characteristics Category No. of study population No. of colorectal cancer Cumulative incidence rate (per 1000) Incidence density (per 10,000 person-years)
Normal Pre-MetS MetS Total Normal Pre-MetS MetS Total Normal Pre-MetS MetS p value Total p value Normal Pre-MetS MetS p value Total p value
Total 841,887 2,037,811 816,225 3,695,923 2174 7858 4517 14,549 2.6 3.9 5.5   3.9   2.8 4.2 6.0   4.2  
Age 30–39 52,090 78,689 19,451 150,230 31 62 11 104 0.6 0.8 0.6 < 0.001 0.7 < 0.001 0.6 0.8 0.6 < 0.001 0.7 < 0.001
40–49 403,228 802,049 267,504 1,472,781 457 1066 422 1945 1.1 1.3 1.6 < 0.001 1.3 1.2 1.4 1.7 < 0.001 1.4
50–59 259,358 695,206 294,199 1,248,763 771 2722 1387 4880 3.0 3.9 4.7 < 0.001 3.9 3.2 4.2 5.1 < 0.001 4.2
60–69 127,211 461,867 235,071 824,149 915 4008 2697 7620 7.2 8.7 11.5 < 0.001 9.2 7.8 9.4 12.5 < 0.001 10.0
Smoking Non-smoker 254,976 551,062 198,274 1,004,312 599 1998 1098 3695 2.3 3.6 5.5 < 0.001 3.7 <0.001 2.5 3.9 6.0 < 0.001 4.0 < 0.001
Ex-smoker 191,807 502,695 209,573 904,075 506 2112 1330 3948 2.6 4.2 6.3 < 0.001 4.4 2.8 4.5 6.8 < 0.001 4.7
Smoker 390,833 975,701 405,252 1,771,786 1061 3718 2076 6855 2.7 3.8 5.1 < 0.001 3.9 2.9 4.1 5.6 < 0.001 4.2
Alcohol consumption No drink 266,110 561,954 205,282 1,033,346 722 2099 1121 3942 2.7 3.7 5.5 < 0.001 3.8 < 0.001 2.9 4.0 5.9 < 0.001 4.1 < 0.001
2–3/per month 435,666 1,015,825 391,247 1,842,738 965 3469 1882 6316 2.2 3.4 4.8 < 0.001 3.4 2.4 3.7 5.2 < 0.001 3.7
1–4/per week 100,885 330,563 157,013 588,461 309 1479 984 2772 3.1 4.5 6.3 < 0.001 4.7 3.3 4.8 6.8 < 0.001 5.1
5/per week 29,429 110,628 56,183 196,240 149 745 503 1397 5.1 6.7 9.0 < 0.001 7.1 5.5 7.3 9.8 < 0.001 7.7
Physical exercise,
per week
No exercise 343,189 841,263 346,095 1,530,547 897 3244 1948 6089 2.6 3.9 5.6 < 0.001 4.0 < 0.001 2.8 4.2 6.1 < 0.001 4.3 < 0.001
1–4/per week 177,100 419,415 167,585 764,100 452 1489 854 2795 2.6 3.6 5.1 < 0.001 3.7 2.7 3.8 5.5 < 0.001 3.9
5/per week 314,767 762,500 297,226 1,374,493 807 3072 1694 5573 2.6 4.0 5.7 < 0.001 4.1 2.7 4.3 6.2 < 0.001 4.4
FHx of cancer No 494,125 1,199,780 486,757 2,180,662 1,176 4376 2520 8072 2.4 3.6 5.2 < 0.001 3.7 < 0.001 2.6 3.9 5.6 < 0.001 4.0 < 0.001
Yes 95,222 217,852 83,206 396,280 234 816 467 1517 2.5 3.7 5.6 < 0.001 3.8 2.6 4.0 6.1 < 0.001 4.1
Height
(cm)
< 167 239,064 636,453 236,248 1,111,765 822 3205 1723 5750 3.4 5.0 7.3 < 0.001 5.2 < 0.001 3.7 5.4 7.2 < 0.001 5.6 < 0.001
167–171 220,547 534,838 209,648 965,033 588 2131 1193 3912 2.7 4.0 5.7 < 0.001 4.1 2.9 4.3 5.6 < 0.001 4.4
172-174 204,006 469,535 192,522 866,063 435 1485 950 2870 2.1 3.2 4.9 < 0.001 3.3 2.3 3.4 4.8 < 0.001 3.6
≥ 175 178,270 396,985 177,807 753,062 329 1037 651 2017 1.8 2.6 3.7 < 0.001 2.7 2.0 2.8 3.6 < 0.001 2.9
Weight
(kg)
< 64 372,420 572,899 83,536 1,028,855 1,106 2,672 646 4,424 3.0 4.7 7.7 < 0.001 4.3 < 0.001 3.2 5.0 8.5 < 0.001 4.6 < 0.001
64-69 235,461 530,335 128,262 894,058 555 2157 871 3583 2.4 4.1 6.8 < 0.001 4.0 2.5 4.4 7.4 < 0.001 4.3
70–76 171,877 534,264 213,956 920,097 397 1852 1277 3526 2.3 3.5 6.0 < 0.001 3.8 2.5 3.7 6.4 < 0.001 4.1
≥ 77 62,129 400,313 390,471 852,913 116 1177 1723 3016 1.9 2.9 4.4 < 0.001 3.5 2.0 3.2 4.8 < 0.001 3.8
BMI
(kg/m2)
< 18.5 33,171 29,275 1,844 64,290 76 144 21 241 2.3 4.9 11.4 < 0.001 3.7 < 0.001 2.5 5.4 13.1 < 0.001 4.1 < 0.001
18.5–22.9 445,140 656,729 83,735 1,185,604 1,138 2617 572 4327 2.6 4.0 6.8 < 0.001 3.6 2.7 4.3 7.4 < 0.001 3.9
23.0–24.9 234,677 621,458 159,332 1,015,467 631 2384 977 3992 2.7 3.8 6.1 < 0.001 3.9 2.9 4.1 6.6 < 0.001 4.2
25.0–29.9 128,038 690,021 477,677 1,295,736 327 2580 2537 5444 2.6 3.7 5.3 < 0.001 4.2 2.7 4.0 5.7 < 0.001 4.5
≥ 30.0 861 40,328 93,637 134,826 2 133 410 545 2.3 3.3 4.4 < 0.001 4.0 2.5 3.6 4.7 < 0.001 4.4
Total cholesterol
(mg/dL)
< 173 287,648 499,111 154,244 941,003 650 1819 886 3355 2.3 3.6 5.7 < 0.001 3.6 < 0.001 2.4 3.9 6.2 < 0.001 3.8 < 0.001
173–194 239,234 504,393 176,051 919,678 615 1886 961 3462 2.6 3.7 5.5 < 0.001 3.8 2.8 4.0 5.9 < 0.001 4.1
195–218 189,771 516,797 210,313 916,881 530 2,044 1,159 3,733 2.8 4.0 5.5 < 0.001 4.1 3.0 4.3 6.0 < 0.001 4.4
≥ 219 125,234 517,510 275,617 918,361 379 2,109 1,511 3,999 3.0 4.1 5.5 < 0.001 4.4 3.3 4.4 5.9 < 0.001 4.7
ALT
(IU/L)
< 18 354,952 530,427 94,775 980,154 880 2,154 628 3,662 2.5 4.1 6.6 < 0.001 3.7 < 0.001 2.7 4.4 7.2 < 0.001 4.0 < 0.001
18–24 241,797 549,667 159,960 951,424 648 2,144 948 3,740 2.7 3.9 5.9 < 0.001 3.9 2.9 4.2 6.4 < 0.001 4.2
25–35 154,775 500,574 221,678 877,027 417 1967 1277 3661 2.7 3.9 5.8 < 0.001 4.2 2.9 4.2 6.2 < 0.001 4.5
≥ 36 90,363 457,143 339,812 887,318 229 1593 1664 3486 2.5 3.5 4.9 < 0.001 3.9 2.7 3.8 5.3 < 0.001 4.2
Hemoglobin
(g/dL)
> 12 836,812 2,025,415 811,497 3,673,724 2,153 7,772 4,476 14,401 2.6 3.8 5.5 < 0.001 3.9 < 0.001 2.8 4.1 6.0 < 0.001 4.2 < 0.001
10–12 4,173 9,967 3,769 17,909 15 64 31 110 3.6 6.4 8.2 < 0.001 6.1 3.9 7.2 9.4 < 0.001 6.9
< 10 624 1,624 623 2,871 5 17 6 28 8.0 10.5 9.6 < 0.001 9.8 8.8 11.9 11.2 < 0.001 11.1
Serum creatinine
(mg/dL)
≤ 1.5 815,023 1,962,815 783,300 3,561,138 2,112 7599 4339 14,050 2.6 3.9 5.5 < 0.001 3.9 < 0.001 2.8 4.2 6.0 < 0.001 4.3 < 0.001
> 1.5 26,813 74,886 32,883 134,582 61 259 178 498 2.3 3.5 5.4 < 0.001 3.7 2.4 3.7 5.8 < 0.001 4.0
  1. MetS metabolic syndrome, FHx family history, BMI body mass index, ALT alanine aminotransferase