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Table 2 Chronic noise exposure Significantly affected gene ontology

From: Transcriptome analysis of the hippocampus in environmental noise-exposed SAMP8 mice reveals regulatory pathways associated with Alzheimer’s disease neuropathology

Go ID

Go Description

P value

Overlap gene name

GO:0007611

learning or memory

0.000154

Egr2; Fos;Hmgcr;Arc

GO:0050890

cognition

0.000235

Egr2; Fos; Hmgcr; Arc

GO:0007612

learning

0.000598

Fos; Hmgcr; Arc

GO:0048168

regulation of neuronal synaptic plasticity

0.001688

Egr2; Arc

GO:0007215

glutamate receptor signaling pathway

0.003899

Homer1; Arc

GO:0008306

associative learning

0.004507

Fos; Hmgcr

GO:0007568

aging

0.004563

Fos; Nuak1; Hmgcr

GO:0050804

modulation of synaptic transmission

0.004607

Egr2; Hap1; Arc

GO:0045073

regulation of chemokine biosynthetic process

0.011953

Egr1

GO:1902992

negative regulation of amyloid precursor protein catabolic process

0.011953

Hap1

GO:0048167

regulation of synaptic plasticity

0.014307

Egr2; Arc

GO:0032230

positive regulation of synaptic transmission, GABAergic

0.015513

Hap1

GO:0007216

G-protein coupled glutamate receptor signaling pathway

0.017879

Homer1

GO:1902003

regulation of beta-amyloid formation

0.017879

Hap1

GO:1902991

regulation of amyloid precursor protein catabolic process

0.021418

Hap1

GO:0034205

beta-amyloid formation

0.022595

Hap1

GO:2000311

regulation of AMPA receptor activity

0.024945

Arc

GO:0032731

positive regulation of interleukin-1 beta production

0.030797

Egr1

GO:1900271

regulation of long-term synaptic potentiation

0.031963

Arc

GO:0050435

beta-amyloid metabolic process

0.033128

Hap1

GO:0032732

positive regulation of interleukin-1 production

0.034292

Egr1

GO:2000772

regulation of cellular senescence

0.034292

Nuak1

GO:0030431

sleep

0.035454

Fos

GO:0032228

regulation of synaptic transmission, GABAergic

0.038933

Hap1

GO:0043666

regulation of phosphoprotein phosphatase activity

0.0424

Nuak1

GO:0090342

regulation of cell aging

0.0424

Nuak1

GO:1900449

regulation of glutamate receptor signaling pathway

0.0424

Arc

GO:1901214

regulation of neuron death

0.04305

Fos; Egr1

GO:0007178

transmembrane receptor protein serine/threonine kinase signaling pathway

0.044463

Fos; Egr1

GO:0042982

amyloid precursor protein metabolic process

0.044705

Hap1

GO:0099601

regulation of neurotransmitter receptor activity

0.044705

Arc

GO:0051932

synaptic transmission, GABAergic

0.047004

Hap1

GO:0032651

regulation of interleukin-1 beta production

0.048152

Egr1