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Table 2 Chronic noise exposure Significantly affected gene ontology

From: Transcriptome analysis of the hippocampus in environmental noise-exposed SAMP8 mice reveals regulatory pathways associated with Alzheimer’s disease neuropathology

Go IDGo DescriptionP valueOverlap gene name
GO:0007611learning or memory0.000154Egr2; Fos;Hmgcr;Arc
GO:0050890cognition0.000235Egr2; Fos; Hmgcr; Arc
GO:0007612learning0.000598Fos; Hmgcr; Arc
GO:0048168regulation of neuronal synaptic plasticity0.001688Egr2; Arc
GO:0007215glutamate receptor signaling pathway0.003899Homer1; Arc
GO:0008306associative learning0.004507Fos; Hmgcr
GO:0007568aging0.004563Fos; Nuak1; Hmgcr
GO:0050804modulation of synaptic transmission0.004607Egr2; Hap1; Arc
GO:0045073regulation of chemokine biosynthetic process0.011953Egr1
GO:1902992negative regulation of amyloid precursor protein catabolic process0.011953Hap1
GO:0048167regulation of synaptic plasticity0.014307Egr2; Arc
GO:0032230positive regulation of synaptic transmission, GABAergic0.015513Hap1
GO:0007216G-protein coupled glutamate receptor signaling pathway0.017879Homer1
GO:1902003regulation of beta-amyloid formation0.017879Hap1
GO:1902991regulation of amyloid precursor protein catabolic process0.021418Hap1
GO:0034205beta-amyloid formation0.022595Hap1
GO:2000311regulation of AMPA receptor activity0.024945Arc
GO:0032731positive regulation of interleukin-1 beta production0.030797Egr1
GO:1900271regulation of long-term synaptic potentiation0.031963Arc
GO:0050435beta-amyloid metabolic process0.033128Hap1
GO:0032732positive regulation of interleukin-1 production0.034292Egr1
GO:2000772regulation of cellular senescence0.034292Nuak1
GO:0030431sleep0.035454Fos
GO:0032228regulation of synaptic transmission, GABAergic0.038933Hap1
GO:0043666regulation of phosphoprotein phosphatase activity0.0424Nuak1
GO:0090342regulation of cell aging0.0424Nuak1
GO:1900449regulation of glutamate receptor signaling pathway0.0424Arc
GO:1901214regulation of neuron death0.04305Fos; Egr1
GO:0007178transmembrane receptor protein serine/threonine kinase signaling pathway0.044463Fos; Egr1
GO:0042982amyloid precursor protein metabolic process0.044705Hap1
GO:0099601regulation of neurotransmitter receptor activity0.044705Arc
GO:0051932synaptic transmission, GABAergic0.047004Hap1
GO:0032651regulation of interleukin-1 beta production0.048152Egr1