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Fig. 3 | Environmental Health and Preventive Medicine

Fig. 3

From: Blocking the PD-1/PD-L1 axis enhanced cisplatin chemotherapy in osteosarcoma in vitro and in vivo

Fig. 3

Interaction between PD-L1 and PD-1 can promote K7M2 cell proliferation. K7M2-LV or K7M2-NC cells were co-cultured with CD4+PD-1+ or CD4+PD-1− lymphocytes for 24, 48, and 72 h. a Cell morphology was observed under microscopes (× 200 magnification). b Relative cell viability was determined using a CCK-8 assay. The experiment was repeated three times, and results are presented as the mean ± standard deviation. **P < 0.01 and ##P < 0.01 vs the K7M2-NC + PD-1− group; %P < 0.05 and %%P < 0.01 vs the K7M2-LV + PD-1− group. PD-L1, programmed death-ligand 1; PD-1, programmed cell death protein

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