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Table 4 Best gene–environment interaction models as identified by GMDR

From: Impact of interleukin-6 gene polymorphisms and its interaction with obesity on osteoporosis risk in Chinese postmenopausal women

Locus no.

Best combination

Cross-validation consistency

Testing accuracy

P values*

Gene–alcohol drinking interaction*

 2

1, 5

6/10

0.522

0.324

 3

1, 3, 5

7/10

0.514

0.255

 4

1, 2, 3, 5

6/10

0.597

0.212

 5

1, 2, 3, 4, 5

7/10

0.523

0.240

Gene–smoking interaction**

 2

3, 6

7/10

0.488

0.536

 3

3, 1, 6

6/10

0.523

0.706

 4

1, 2, 3, 6

5/10

0.536

0.862

 5

1, 2, 3, 4, 6

6/10

0.518

0.377

Gene–obesity interaction***

 2

1, 7

10/10

0.641

0.012

 3

1, 2,7

8/10

0.526

0.266

 4

1, 2, 4, 7

9/10

0.514

0.545

 5

1, 2, 3, 4, 7

5/10

0.634

0.372

  1. *Adjusted for age, smoke, and obesity
  2. **Adjusted for age, alcohol consumption status, and obesity
  3. ***Adjusted for age, smoke, and alcohol consumption status
  4. Numbers 1–7 represent rs1800796, rs1800795, rs2069849, rs1554606, alcohol drinking, smoking, and obesity, respectively
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Environmental Health and Preventive Medicine

ISSN: 1347-4715

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