Table 3 The association of genotype and allele within four SNPs with OP risk
SNPs | Genotypes and alleles | Frequencies N(%) | OR (95% CI) * | HWE test | |
|---|---|---|---|---|---|
OP patients (n = 758) | Controls (n = 766) | ||||
rs1800796-572C/G | CC | 377 (49.7) | 469 (61.2) | 1.00 | 0.346 |
CG | 300 (39.6) | 255 (33.3) | 1.39 (1.09–1.65) | ||
GG | 81 (10.7) | 42 (5.5) | 1.90 (1.29–2.54) | ||
CG + GG | 381 (50.3) | 297 (38.8) | 1.47 (1.13–1.78) | ||
C | 1054 (69.5) | 1193 (77.9) | |||
G | 462 (30.5) | 339 (22.1) | |||
rs1800795-174G/C | GG | 399 (52.6) | 440 (57.4) | 1.00 | 0.106 |
GC | 285 (37.6) | 270 (35.2) | 1.07 (0.94–1.39) | ||
CC | 74 (9.8) | 56 (7.3) | 1.12 (0.85–1.60) | ||
GC + CC | 359 (47.4) | 326 (42.6) | 1.09 (0.91–1.44) | ||
G | 1083 (71.4) | 1150 (75.1) | |||
C | 433 (28.6) | 382 (24.9) | |||
rs2069849 | CC | 384 (50.7) | 481 (62.8) | 1.00 | 0.730 |
CT | 306 (40.4) | 250 (32.6) | 1.65 (1.38–1.90) | ||
TT | 68 (9.0) | 35 (4.6) | 2.03 (1.63–2.84) | ||
CT + TT | 374 (49.3) | 285 (37.2) | 1.74 (1.46–2.05) | ||
C | 1074 (70.8) | 1212 (79.1) | |||
T | 442 (29.2) | 320 (20.9) | |||
rs1554606 (185C/A) | CC | 405 (53.4) | 447 (58.4) | 1.00 | 0.272 |
CA | 292 (38.5) | 269 (35.1) | 1.08 (0.91–1.36) | ||
AA | 61 (8.1) | 50 (6.5) | 1.04 (0.82–1.53) | ||
CA + AA | 353 (46.6) | 319 (41.6) | 1.07 (0.89–1.39) | ||
C | 1102 (72.7) | 1163 (75.9) | |||
A | 414 (27.3) | 369 (24.1) | |||