Fig. 1

Age differences in hydrolysis activity of DEHP in the hepatic microsome. The livers were removed from fetuses at GD 28 and PND2 and at 3 and 23 months of age. Analytical methods were described elsewhere [11]. Data indicates the mean ± standard deviation. The white and black columns indicate WT and KO, respectively. ^#Significantly different (p < 0.05) from those of other ages in WT. ^†Significantly different from those of other ages in KO. ^§Significantly different from that in WT. WT, wild-type mice; KO, Pparα-null mice. White and black bars indicate WT and KO, respectively. n = 4–9