Associations between metal concentrations in whole blood and placenta previa and placenta accreta: the Japan Environment and Children’s Study (JECS)

Tsuji, Mayumi; Shibata, Eiji; Askew, David J.; Morokuma, Seiichi; Aiko, Yukiyo; Senju, Ayako; Araki, Shunsuke; Sanefuji, Masafumi; Ishihara, Yasuhiro; Tanaka, Rie; Kusuhara, Koichi; Kawamoto, Toshihiro

doi:10.1186/s12199-019-0795-7

Environmental Health and Preventive Medicine

Table 3 Results of multivariable analysis regarding the relationship between quartile concentrations of metals, placenta previa, and placenta accreta

From: Associations between metal concentrations in whole blood and placenta previa and placenta accreta: the Japan Environment and Children’s Study (JECS)

Quartile concentration of metals (ng/g)	Previa				Accreta
Quartile concentration of metals (ng/g)	Without (N = 15,929)	With (N = 90)	OR (95% CI)	p value*	Without (N = 15,980)	With (N = 39)	OR (95% CI)	p value **
Cd
Q1 (≤ 0.496)	3967	14	1.00 (referent)		3971	10	1.00 (referent)
Q2 (0.497–0.661)	3999	20	1.37 (0.69–2.72)	0.375	4012	7	0.55 (0.21–1.46)	0.234
Q3 (0.662–0.904)	3982	25	1.67 (0.86–3.26)	0.129	3993	14	1.01 (0.44–2.33)	0.981
Q4 (≥ 0.905)	3981	31	2.06 (1.07–3.98)	0.031	4004	8	0.46 (0.17–1.22)	0.120
			P for trend =	0.146			P for trend =	0.205
Pb
Q1 (≤4.79)	3969	14	1.00 (referent)		3976	7	1.00 (referent)
Q2 (4.80–5.95)	3987	37	2.59 (1.40–4.80)	0.003	4012	12	1.46 (0.57–3.76)	0.429
Q3 (5.96–7.44)	3975	19	1.32 (0.66–2.64)	0.436	3981	13	1.68 (0.66–4.24)	0.276
Q4 (≥ 7.45)	3998	20	1.34 (0.67–2.67)	0.411	4011	7	0.79 (0.27–2.30)	0.667
			P for trend =	0.007			P for trend =	0.345
Hg
Q1 (≤ 2.56)	3948	20	1.00 (referent)		3959	9	1.00 (referent)
Q2 (2.57–3.64)	3987	29	1.37 (0.78–2.44)	0.276	4003	13	1.31 (0.55–3.08)	0.540
Q3 (3.65–5.15)	4004	19	0.89 (0.47–1.67)	0.708	4012	11	1.18 (0.48–2.86)	0.721
Q4 (≥ 5.16)	3990	22	1.03 (0.56–1.90)	0.924	4006	6	0.63 (0.22–1.77)	0.378
			P for trend =	0.477			P for trend =	0.458
Se
Q1 (≤ 157)	3961	27	1.00 (referent)		3978	10	1.00 (referent)
Q2 (158–168)	3687	21	0.84 (0.47–1.49)	0.544	3700	8	0.86 (0.34–2.20)	0.756
Q3 (169–182)	4197	21	0.73 (0.41–1.30)	0.284	4209	9	0.83 (0.34–2.07)	0.695
Q4 (≥ 183)	4084	21	0.75 (0.42–1.33)	0.320	4093	12	1.13 (0.48–2.63)	0.784
			P for trend =	0.693			P for trend =	0.901
Mn
Q1 (≤ 12.5)	3858	21	1.00 (referent)		3871	8	1.00 (referent)
Q2 (12.6–15.2)	3961	22	1.05 (0.58–1.91)	0.877	3966	17	2.11 (0.91–4.92)	0.083
Q3 (15.3–18.6)	4100	23	1.06 (0.58–1.92)	0.853	4116	7	0.82 (0.31–2.29)	0.710
Q4 (≥ 18.7)	4010	24	1.14 (0.63–2.06)	0.656	4027	7	0.85 (0.31–2.37)	0.758
			P for trend =	0.977			P for trend =	0.080

*p values were obtained from the multivariable logistic regression analysis adjusted for age, smoking, smoking habits of the partner, drinking habits, gravidity, parity, number of cesarean deliveries, and geographic region
**p values were obtained from the multivariable logistic regression analysis adjusted for age, smoking, smoking habits of the partner, drinking habits, gravidity, parity, number of cesarean deliveries, placenta previa, and geographic region

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