Analysis of individual and combined estrogenic effects of bisphenol, nonylphenol and diethylstilbestrol in immature rats with mathematical models

Table 3 The MDRs between predeiction and tested results of uterus/body weight ratio treated with combination of BPA, NP and DES

group	uterus/body weight ratio (g/kg, %)	weight gain rate of the uterus(%)	predicted effective concentration (mg/kg bw)	MDR	combined effect
BMDL₁₀
BPA + NP	0.95 ± 0.27	26.59 ± 35.85	189.31	1.93	additive
BPA + DES	0.87 ± 0.21	17.11 ± 28.05	119.44	1.30	additive
NP + DES	0.80 ± 0.17	7.21 ± 22.52	3.77	0.63	additive
BPA + NP + DES	0.92 ± 0.23	22.61 ± 31.33	161.82	1.10	additive
LOAEL
BPA + NP	1.00 ± 0.19	33.53 ± 25.26	250.22	0.97	additive
BPA + DES	1.08 ± 0.25	44.90 ± 32.99	174.08	0.73	additive
NP + DES	0.93 ± 0.12	24.66 ± 15.87	7.21	0.48	antagonistic
BPA + NP + DES	1.06 ± 0.11	41.33 ± 14.81	139.12	0.54	additive

BPA Bisphenol A, NP Nonylphenol, DES Diethylstilbestrol, BMDL Benchmark dose lower confidence limit, LOAEL Lowest observed adverse effect level

ISSN: 1347-4715