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Table 2 Results of factorial analysis for the relative weight of uterus treated with combination of BPA,NP and DES(n = 10)

From: Analysis of individual and combined estrogenic effects of bisphenol, nonylphenol and diethylstilbestrol in immature rats with mathematical models

group

BMDL10

LOAEL

uterus/body weight ratio (g/kg, %)

F Value

P-Value

uterus/body weight ratio (g/kg, %)

F Value

P-Value

Variance source

 Blank control

0.79 ± 0.08

–

–

0.79 ± 0.08

–

–

 vehicle control

0.75 ± 0.14

–

–

0.75 ± 0.14

–

–

Main effect

 BPA

0.80 ± 0.20

3.65

0.06

0.95 ± 0.23

11.87

P < 0.05

 NP

0.79 ± 0.22

1.00

0.32

0.93 ± 0.18

1.71

0.20

 DES

0.85 ± 0.19

0.72

0.40

0.93 ± 0.16

5.57

P < 0.05

Interaction

 BPA + NP

0.95 ± 0.27

1.07

0.31

1.00 ± 0.19

1.09

0.30

 BPA + DES

0.87 ± 0.21

0.12

0.73

1.08 ± 0.25

0.003

0.96

 NP + DES

0.80 ± 0.17

1.07

0.31

0.93 ± 0.12

2.69

0.11

 BPA + NP + DES

0.92 ± 0.23

0.01

0.911

1.06 ± 0.11

0.49

0.49

  1. ANOVA was used to test the statistical significance for the main effect and interaction. “P < 0.05” indicated statistically significant main effect for individula EDCs or interactions among EDCs
  2. BPA Bisphenol A; NP Nonylphenol, DES Diethylstilbestrol, BMDL Benchmark dose lower confidence limit,LOAEL Lowest observed adverse effect level
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Environmental Health and Preventive Medicine

ISSN: 1347-4715

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