Analysis of individual and combined estrogenic effects of bisphenol, nonylphenol and diethylstilbestrol in immature rats with mathematical models

Table 1 Dose combination of DES, BAP and NP

Group	n	Mixture Doses (mg/kg body weight)
blank control	10	water
vehicle control	10	Corn oil
BMDL₁₀
BPA	10	92
NP	10	6
DES	10	0.1
BPA + NP	10	92 + 6
BPA + DES	10	92 + 0.1
NP + DES	10	6 + 0.1
BPA + NP + DES	10	92 + 6 + 0.1
LOAEL
BPA	10	240
NP	10	15
DES	10	0.5
BPA + NP	10	240+ 15
BPA + DES	10	240+ 0.5
NP + DES	10	15 + 0.5
BPA + NP + DES	10	240+ 15+ 0.5

BPA Bisphenol A, NP Nonylphenol, DES Diethylstilbestrol, BMDL Benchmark dose lower confidence limit, LOAEL Lowest observed adverse effect level

ISSN: 1347-4715