Table 2 Multivariable-adjusted odds ratio for the development of chronic pancreatitis in participants with fatty pancreas
|  | Chronic pancreatitis | No chronic pancreatitis | Univariate analysis n = 9933 | Multivariable analysis* n = 9933 | |||||
|---|---|---|---|---|---|---|---|---|---|
n = 92 | n = 9841 | Crude OR with 95% CI | AUC | Adjusted OR with 95% CI | Tolerance | VIF | Condition index | AUC | |
Fat accumulation | |||||||||
 Normal pancreas, n (%) | 80 (0.82) | 9630 (99.18) | Reference | 0.555 | Reference | 0.982 | 1.018 | 3.139 | 0.802 |
 Fatty pancreas, n (%) | 12 (5.38) | 211 (94.62) | 6.846 (3.676, 12.750) |  | 3.957 (2.043, 7.664) |  | |||
Demographics | |||||||||
 Age, mean (SD) | 54.72 (9.68) | 46.67 (8.67) | 1.095 (1.073, 1.118) | 0.728 | 1.099 (1.072, 1.127) | 0.821 | 1.218 |  | |
 Women, n (%) | 20 (0.41) | 4857 (99.59) | Reference | 0.638 | Reference | 0.600 | 1.667 | ||
 Men, n (%) | 72 (1.42) | 4984 (98.58) | 3.508 (2.134, 5.767) |  | 1.943 (1.065, 3.542) |  | |||
 Body mass index, mean (SD) | 22.93 (2.77) | 22.27 (3.05) | 1.067 (1.004, 1.133) | 0.575 | 0.971 (0.890, 1.059) | 0.668 | 1.500 | ||
 Systolic blood pressure, mean (SD) | 115.7 (15.04) | 109.17 (14.42) | 1.027 (1.015, 1.039) | 0.629 | 0.999 (0.978, 1.020) | 0.429 | 2.329 | ||
 Pulse pressure, mean (SD) | 47.39 (9.83) | 44.07 (8.75) | 1.038 (1.018, 1.060) | 0.605 | 1.010 (0.980, 1.042) | 0.529 | 1.889 | ||
Laboratory data | |||||||||
 AST/ALT, mean (SD) | 1.05 (0.33) | 1.15 (0.36) | 0.436 (0.232, 0.820) | 0.581 | 0.444 (0.203, 1.001) | 0.728 | 1.374 |  | |
 Gamma-glutamyltransferase, mean (SD) | 56.01 (68.97) | 36.11 (46.96) | 1.004 (1.002, 1.006) | 0.644 |  | ||||
 LDL/HDL, mean (SD) | 2.03 (0.69) | 1.96 (0.7) | 1.131 (0.850, 1.504) | 0.529 | 0.878 (0.633, 1.220) | 0.772 | 1.295 | ||
 Fasting blood glucose, mean (SD) | 101.55 (13.47) | 97.18 (14.24) | 1.011 (1.004, 1.019) | 0.631 | 0.999 (0.979, 1.019) | 0.391 | 2.558 | ||
 Hemoglobin A1c, mean (SD) | 5.72 (0.49) | 5.55 (0.51) | 1.424 (1.140, 1.779) | 0.611 | 0.972 (0.557, 1.697) | 0.403 | 2.480 | ||
Lifestyle factors | |||||||||
 Ethanol intake, n (%) | |||||||||
 None, n (%) | 46 (0.68) | 6684 (99.32) | Reference | 0.605 | Reference | 0.765 | 1.307 |  | |
 1–139 g/week, n (%) | 10 (0.97) | 1018 (99.03) | 1.427 (0.718, 2.837) |  | 0.971 (0.476, 1.977) |  | |||
 140–279 g/week, n (%) | 18 (1.27) | 1396 (98.73) | 1.874 (1.083, 3.241) | 1.084 (0.597, 1.971) | |||||
 ≤ 280 g/week, n (%) | 18 (2.37) | 743 (97.67) | 3.520 (2.031, 6.102) | 1.933 (1.023, 3.652) | |||||
 Smoking, n (%) | |||||||||
 Brinkman index = 0, n (%) | 55 (0.7) | 7832 (99.3) | Reference | 0.607 | Reference | 0.856 | 1.169 |  | |
 0 < Brinkman index < 200, n (%) | 2 (0.62) | 323 (99.38) | 0.882 (0.214, 3.631) |  | 1.415 (0.337, 5.936) |  | |||
 200 ≤ Brinkman index < 400, n (%) | 9 (1.75) | 504 (98.25) | 2.543 (1.250, 5.175) | 3.529 (1.657, 7.517) | |||||
 400 ≤ Brinkman index, n (%) | 26 (2.15) | 1182 (97.85) | 3.132 (1.957, 5.014) | 1.922 (1.145, 3.224) |  |  | |||