The association between IGF1 gene rs1520220 polymorphism and cancer susceptibility: a meta-analysis based on 12,884 cases and 58,304 controls

Table 3 Meta-analysis of the association between IGF1 rs1520220 polymorphism and cancer susceptibility

Subgroup	No.	C vs. G			CC vs. GG			GC vs. GG			CC + GC vs. GG			CC vs. GC + GG
Subgroup		OR (95%Cl)	P _OR	P _h	OR (95%Cl)	P _OR	P _h	OR (95%Cl)	P _OR	P _h	OR (95%Cl)	P _OR	P _h	OR (95%Cl)	P _OR	P _h
Overall	8	1.01 (0.95–1.08)^*	0.715	0.026	1.08 (0.90–1.30)^*	0.415	0.010	1.05 (0.97–1.13)	0.268	0.374	1.05 (0.97–1.13)	0.237	0.163	1.02 (0.91–1.13)^*	0.773	0.026
Caucasian	2	1.00 (0.84–1.20)^*	0.953	0.010	1.16 (0.58–2.31)^*	0.675	0.001	0.98 (0.87–1.10)	0.743	0.330	0.97 (0.77–1.21)^*	0.762	0.08	1.21 (0.68–2.15)^*	0.524	0.002
Asian	4	1.10 (1.00–1.21)	0.040	0.455	1.22 (1.01–1.47)	0.040	0.426	1.17 (0.99–1.39)	0.066	0.382	1.19 (1.01–1.39)	0.033	0.324	1.10 (0.95–1.26)	0.215	0.762
Breast cancer	4	1.00 (0.95–1.05)	0.978	0.130	1.15 (0.87–1.51)^*	0.320	0.053	1.04 (0.94–1.15)	0.425	0.713	1.05 (0.96–1.15)	0.289	0.703	1.11 (0.86–1.42)^*	0.428	0.016
Quality score ≥ 12	7	1.01 (0.94–1.08)^*	0.875	0.021	1.07 (0.87–1.31)^*	0.542	0.006	1.04 (0.96–1.13)	0.292	0.275	1.04 (0.97–1.12)	0.283	0.112	1.01 (0.90–1.13)^*	0.922	0.023

OR odds ratio, 95% CI 95% confidence interval, P_OR, pool p value; P_h, p value of heterogeneity test
*Indicates that the OR, 95% Cl, and corresponding P_OR were calculated based on the random-effects model; otherwise, the fixed-effects model was used. Italic values are statistically significant (P < 0.05)

ISSN: 1347-4715