Interactions between ALDH2 rs671 polymorphism and lifestyle behaviors on coronary artery disease risk in a Chinese Han population with dyslipidemia: A guide to targeted heart health management

Table 5 Interaction between ALDH2 rs671 polymorphism and physical activity on CAD risk

	ALDH2 rs671 polymorphism genotype
	Non-risk allele carriers (G/G)		Risk allele carriers (A/A + A/G)		OR^† (95% CI) for A/A + G/G within strata of physical activity
	N cases/controls	OR^† (95% CI)	N cases/controls	OR^† (95% CI)
Moderate/heavy physical activity	12/59		9/49
Moderate/heavy physical activity		1.0		0.793 (0.299–2.101) P = 0.640	0.793 (0.299–2.101) P = 0.640
Sedentary/light physical activity	60/215		80/172
		1.345 (0.669–2.701) P = 0.406		2.071 (1.013–4.234) P = 0.046	1.540 (1.012–2.344)
		1.345 (0.669–2.701) P = 0.406		2.071 (1.013–4.234) P = 0.046	P = 0.044
OR^† (95% CI) for sedentary/light physical activity within strata of genotype		1.345 (0.669–2.701) P = 0.406		2.612 (1.202–5.674) P = 0.015

Measure of interaction on additive scale: RERI (95% CI) = 0.933 (0.021 to 1.845); P value = 0.045
^†Adjusted for age, sex, BMI, SBP, TC level, TG level, HDL-C level, current smoking, current alcohol intake, and history of diabetes mellitus
Italic values are statistically significant with P value < 0.05 and maintains significance using the Benjamini–Hochberg procedure with the false discovery rate at 0.12

ISSN: 1347-4715