Table 2 Histopathological changes of hepatic cells in rats exposure to different concentrations of fluoride
From: Effect of fluoride on major organs with the different time of exposure in rats
Groups | Portal inflammation | Lytic necrosis | Knodell scorea | Interpretation | |
|---|---|---|---|---|---|
15 days | Control | 0 | 0 | 0 | No inflammation |
0.5 ppm | 0 | 0 | 0 | No inflammation | |
5 ppm | 1 | 1 | 2 | Minimal inflammation | |
20 ppm | 1 | 1 | 2 | Minimal inflammation | |
30 days | Control | 0 | 0 | 0 | No inflammation |
0.5 ppm | 0 | 1 | 1 | Minimal inflammation | |
5 ppm | 1 | 1 | 2 | Minimal inflammation | |
20 ppm | 1 | 3 | 4 | Minimal inflammation | |
60 days | Control | 0 | 0 | 0 | No inflammation |
0.5 ppm | 1 | 3 | 4 | Minimal inflammation | |
5 ppm | 3 | 3 | 6 | Mild inflammation | |
20 ppm | 3 | 3 | 6 | Mild inflammation | |
Portal inflammation: 0, no portal inflammation, 1, mild (sprinkling of inflammatory cells in < 1/3 of portal tracts), 3, moderate (increased inflammatory cells in 1/3–2/3 of portal tracts), 4, marked (dense packing of inflammatory cells in > 2/3 of portal tracts). | Necrosis: 0, none, 1, mild (acidophilic bodies, ballooning degeneration, and/ or scattered foci of hepatocellular necrosis in < 1/3 of lobules or nodules) 3, moderate (involvement of 1/3–2/3 of lobules or nodules) 4, marked (involvement of > 2/3 of lobules or nodules) | ||||