Independent variables | Unadjusted model | Age- and sex-adjusted model | Fully adjusted model | ||||
---|---|---|---|---|---|---|---|
βS (βU) [95% CI] | p value | βS (βU) [95% CIc] | p value | βS (βU) [95% CIc] | p value | ||
f(HMA)a | − 0.25 (− 0.018) [− 0.027, − 0.010] | < 0.01 | − 0.10 (− 0.007) [− 0.016, 0.001] | 0.09 | − 0.13 (− 0.010) [− 0.018, − 0.001] | 0.03 | |
Sex (male) | − 0.28 (− 0.277) [− 0.388, − 0.165] | < 0.01 | − 0.24 (− 0.230) [− 0.340, − 0.130] | < 0.01 | − 0.15 (− 0.151) [− 0.294, − 0.009] | 0.04 | |
Age | 0.42 (0.023) [0.017, 0.028] | < 0.01 | 0.35 (0.019) [0.012, 0.025] | < 0.01 | 0.32 (0.017) [0.010, 0.025] | < 0.01 | |
Body mass index | − 0.01 (− 0.002) [− 0.018, 0.014] | 0.84 | − 0.12 (− 0.016) [− 0.031, − 0.001] | 0.04 | |||
Mean blood pressureb | 0.26 (0.009) [0.005, 0.014] | < 0.01 | 0.13 (0.005) [0.000, 0.009] | 0.03 | |||
Blood glucose | 0.16 (0.005) [0.001, 0.009] | 0.01 | 0.07 (0.002) [− 0.002, 0.006] | 0.27 | |||
Triacylglycerides | 0.01 (0.000) [− 0.001, 0.001] | 0.82 | − 0.02 (0.000) [− 0.001, 0.001] | 0.68 | |||
HDL cholesterol | − 0.14 (− 0.005) [− 0.008, − 0.001] | 0.02 | − 0.02 (− 0.001) [− 0.005, 0.004] | 0.80 | |||
LDL cholesterol | 0.02 (0.000) [− 0.001, 0.002] | 0.72 | 0.11 (0.002) [0.000, 0.003] | 0.04 | |||
Smoking status | Ever | 0.09 (0.097) [− 0.029, 0.223] | 0.13 | 0.07 (0.075) [− 0.062, 0.211] | 0.28 | ||
Current | 0.00 (− 0.006) [− 0.189, 0.177] | 0.95 | 0.05 (0.074) [− 0.105, 0.253] | 0.42 | |||
Alcohol consumption | Ever | 0.14 (0.329) [0.054, 0.605] | 0.02 | 0.10 (0.235) [− 0.020, 0.490] | 0.07 | ||
Current | 0.11 (0.112) [− 0.007, 0.232] | 0.07 | 0.03 (0.026) [− 0.100, 0.152] | 0.69 | |||
Exercise habits | 1–2 h/week | 0.09 (0.098) [− 0.042, 0.239] | 0.17 | 0.07 (0.082) [− 0.047, 0.211] | 0.21 | ||
3–4 h/week | 0.07 (0.107) [− 0.080, 0.294] | 0.26 | 0.05 (0.072) [− 0.096, 0.240] | 0.40 | |||
≥ 5 h/week | 0.16 (0.238) [0.058, 0.419] | 0.01 | 0.08 (0.118) [− 0.051, 0.287] | 0.17 | |||
Medication for non-communicable diseases (present) | 0.17 (0.176) [0.058, 0.295] | < 0.01 | 0.04 (0.043) [− 0.080, 0.165] | 0.49 |