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Table 3 Association between HAA intake and prostate cancer

From: Association between NAT2, CYP1A1, and CYP1A2 genotypes, heterocyclic aromatic amines, and prostate cancer risk: a case control study in Japan

  Mean (SD) Cases Controls OR (95% CI)a
Total HAAs (ng/day)
 Low tertile 17.5 (7.1) 100 131 1.00
 Moderate tertile 35.6 (5.3) 108 124 1.14 (0.83–1.58)
 High tertile 72.9 (29.2) 143 96 1.90 (1.40–2.59)
 Trend Pb     < 0.001
Total Trp-P-1 (ng/day)
 Low tertile 0.44 (0.55) 104 129 1.00
 Moderate tertile 2.9 (0.55) 104 128 1.05 (0.76–1.45)
 High tertile 7.2 (5.0) 143 94 1.92 (1.42–2.61)
 Trend P     < 0.001
Total MeIQ (ng/day)
 Low tertile 2.3 (0.93) 100 131 1.00
 Moderate tertile 4.5 (0.57) 109 123 1.18 (0.85–1.63)
 High tertile 9.0 (3.7) 142 97 1.87 (1.38–2.55)
 Trend P     < 0.001
Total MeIQx (ng/day)
Low tertile 2.4 (0.98) 99 132 1.00
Moderate tertile 4.9 (0.71) 102 130 1.05 (0.76–1.46)
High tertile 9.9 (3.9) 150 89 2.25 (1.65–3.06)
Trend P     < 0.001
Total PhIP (ng/day)
 Low tertile 10.5 (4.2) 102 129 1.00
 Moderate tertile 21.5 (3.2) 106 126 1.06 (0.77–1.48)
 High tertile 44.7 (18.3) 143 96 1.84 (1.35–2.50)
 Trend P     < 0.001
  1. BMI body mass index; OR oratio; 95% CI 95% confidence interval; HAA heterocyclic aromatic amine; Trp-P-1 3-Amino-1, 4-dimethyl-5H-pyrido[4, 3-b]indole; MeIQ 2-Amino-3,4-dimethylimidazo[4,5-f]quinoline; MeIQx 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline; PhIP 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
  2. aORs (95% CI) adjusted by conditional logistic regression for alcohol intake, smoking status, BMI, family history of prostate cancer, and total energy intake
  3. b P value for Cochran–Armitage test for trend