Fig. 2
From: The different roles of innate immune receptors in inflammation and carcinogenesis between races
Mutations in NLR that cause immune-related diseases. NOD1 variant E266K associated with sarcoidosis was found in Japanese population. Three mutations in NOD domain of NOD2 (R334W, R334Q, and L469F) exist both in Blau syndrome in Caucasians and EOS in Japanese cohort. NOD2 SNPs near or within the LRRs of Nod2 (R702W, G908R, L1007insC) are associated with the development of CD in Caucasians that does not exist in Japanese cohort