Fig. 1
From: The different roles of innate immune receptors in inflammation and carcinogenesis between races
Innate immune receptors, NLRs and TLRs. The main members of the innate immune system are NLRs (membrane binding) and TLRs (in the cytosol). NLRs and TLRs sense intracellular and extracellular PAMPs, respectively. The subsequent activation of inflammatory cytokines including IL-6 and NF-ÎşB results in the inflammation, apoptosis, and autophagy. These pathways are involved in the induction of acquired immunity