Fig. 1

Effect of pretreatment with SE on levels of hepatic injury markers. Mice received SE or vehicle (saline) by oral gavage once daily for a week. Twenty-four hours after final SE administration, 550 mg/kg of APAP was injected intraperitoneally. Mice were fasted for 16 h before APAP injection. Plasma levels of hepatic injury markers were determined 2, 6, 24, and 72 h after administration of APAP. Panels a and b indicate ALT and AST, respectively. Data are plotted as mean ± SD for groups of six mice each. Single asterisk indicates p < 0.05 versus control group, double asterisk indicates p < 0.01 versus control group, and number sign indicates p < 0.05 versus APAP group