Table 2 Items measured in The Hokkaido Study on Environment and Children’s Health
From: The Hokkaido Birth Cohort Study on Environment and Children’s Health: cohort profile—updated 2017
Measurement | Method | Specimen |
|---|---|---|
Exposure measurements | ||
Dioxins, PCBs, OH-PCBs (congener level) | HRGC/HRMS | Maternal blood, milk |
PFOS, PFOA, and other PFASs | UPLC-MS/MS | Maternal blood |
Phthalate metabolites | GC-MS, LC-MS/MS | Maternal blood, child urine |
Chlorinated pesticides | GC-NCIMS, GC-HRMS | Maternal blood |
Cotinine | ELISA | Maternal and cord blood |
Bisphenol A | ID-LC-MS/MS | Maternal and cord blood |
Me-Hg | Oxygen combustion-gold amalgamation method | Maternal hair |
Phthalate esters and organophosphate flame retardants | GC-MS | House dust |
Mite allergens | ELISA | House dust |
Biological measurements | ||
Thyroid hormones (TSH, FT3, FT) | ELISA | Maternal and cord blood |
Folic acid | CLEIA | Maternal blood |
Fatty acids (palmitic, stearic, palmitoleic, oleic, linoleic, arachidonic, α-linolenic, EPA, DHA) | GC-MS | Maternal blood |
TG | TC E-Test Wako | Maternal blood |
IgE, IgA | ELISA | Cord blood |
Adipokines (adiponectin, leptin) | ELISA and RIA | Cord blood |
Steroid hormones (estradiol, testosterone, progesterone, cortisol, cortisone, DHEA, androstenedione) | LC-MS/MS | Cord blood |
Reproductive hormones (inhibin B, INSL-3, SHBG, FSH, LH) | ELISA, RIA, EIA | Cord blood |