Table 11 Adverse effects of infant birth weight in relation to maternal environmental exposure and genetic polymorphisms
From: The Hokkaido Birth Cohort Study on Environment and Children’s Health: cohort profile—updated 2017
Environmental exposure | Maternal genetic polymorphism | Maternal risk genotypes | Birth weight reduction (g) | Reference |
|---|---|---|---|---|
Active smoking | AhR (G>A, Arg554Lys) | Arg/Arg | −211 | [22] |
CYP1A1 (m1/m2) | m1/m2 + m2/m2 | −170 | ||
GSTM1 (non-null/null) | Null | −171 | ||
Combination with AhR (G>A, Arg554Lys) and CYP1A1 (m1/m2) | Arg/Arg (AhR) and m1/m2 + m2/m2 (CYP1A1) | −315 | ||
Combination with CYP1A1 (m1/m2) and GSTM1 (non-null/null) | m1/m2 + m2/m2 (CYP1A1) and null (GSTM1) | −237 | ||
NQO1 (C>T, Pro187Ser) | Pro/Pro | −159 | [62] | |
CYP2E1 (c1/c2) | c1/c1 | −195 | ||
MTHFR (A1298C) | AA | −106 | [63] | |
CYP1A1 (A>G, Ile462Val) | AG/GG | −62 | [61] | |
XRCC1 (C>T, Arg194Trp) | CT/TT | −59 | ||
Combination with AhR (G>A, Arg554Lys), CYP1A1 (A>G, Ile462Val), and XRCC1 (C>T, Arg194Trp) | GG (AhR), AG/GG (CYP1A1), and CT/TT (XRCC1) | −145 | ||
Dioxin (total TEQ) | GSTM1 (non-null/null) | Null | −345 | [59] |