Table 10 Findings from the Sapporo and Hokkaido cohorts on the relationships between exposures and allergies and infectious diseases
From: The Hokkaido Birth Cohort Study on Environment and Children’s Health: cohort profile—updated 2017
Exposures | Outcome | Number | Findings | Reference |
|---|---|---|---|---|
Sapporo cohort | ||||
Dioxins | Otitis media | 364 | Polychlorinated dibenzofuran was associated with increased risk among male infants (OR 2.5, 95% CI 1.1–5.9). 2,3,4,7,8-pentachlorodibenzo-furan was associated with increased risk of otitis media (OR 5.3, 95% CI 1.5–19). | [53] |
PFASs | Cord IgE/infectious disease | 343 | Cord IgE levels decreased with high maternal PFOA concentration among females. No associations among maternal PFOS and PFOA levels and food allergy, eczema, wheezing, or otitis media in the 18-month-old infants. | [54] |
Hokkaido cohort | ||||
PFASs | Eczema | 2063 | At 24 months, the risk in association with higher maternal PFTrDA levels decreased (OR 0.62, 95% CI 0.45–0.86). | [32] |
Total allergic diseases/eczema/wheezing | 1558 | ORs in the Q4 vs. Q1 for total allergic diseases decreased for PFDoDA (OR 0.621, 95% CI 0.454–0.847) and PFTrDA (OR 0.712, 95% CI 0.524–0.966). OR (Q4 vs. Q1) for wheezing in relation to higher maternal PFHxS levels was 0.728 (95% CI 0.497–1.06). | [56] | |
Infectious diseases | 1558 | PFHxS was associated with higher risk of total infections disease among girls (Q1 vs. Q4: OR 1.55, 95% CI 0.976–2.45). | [55] | |