Fig. 4
From: A new horizon of moyamoya disease and associated health risks explored through RNF213
Lowered adaptive cerebral angiogenesis after exposure to hypoxia in transgenic mice expressing RNF213 R4757K in endothelial cells. a Several lines of transgenic or knockout or wild-type mice were exposed to hypoxia for 2Â weeks at 8Â % oxygen. Cerebral angiogenesis was evaluated by immunostaining Glut4. b Adaptive cerebral angiogenesis was abolished in transgenic mice overexpressing RNF213 R4757K (Human allelic ortholog of R4810K) in ECs, while in other mice adaptive angiogenesis was observed. Cited from Kobayashi et al. [21]