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Table 3 Crude prevalence of birth defects and RR with 95 % CI according to plurality and the method of treatment by birth year period (2007–2012, live births)

From: Birth defects after assisted reproductive technology according to the method of treatment in Japan: nationwide data between 2004 and 2012

  Fresh embryo transfer FET RR (95 % CI)
Fresh vs. FET
IVF ICSI RR (95 % CI)
ICSI vs. IVF
Total
Live births Prevalence (%) Live births Prevalence (%) Live births Prevalence (%) Live births Prevalence (%)
Singletons
 2007–2009 12,389 148 (1.19) 12,767 177 (1.39) 1.16 (0.93–1.44) 25,156 325 (1.29) 33,499 415 (1.24) 1.04 (0.90–1.21)
 2010–2012 12,739 188 (1.48) 14,745 210 (1.42) 0.97 (0.79–1.17) 27,484 398 (1.45) 63,209 840 (1.33) 1.09 (0.97–1.23)
 Total 25,128 336 (1.34) 27,512 387 (1.41) 1.05 (0.91–1.22) 52,640 723 (1.37) 96,708 1255 (1.30) 1.06 (0.97–1.16)
Multiple births
 2007–2009 2465 25 (1.01) 2222 35 (1.58) 1.55 (0.93–2.59) 4687 60 (1.28) 4622 75 (1.62) 0.79 (0.56–1.11)
 2010–2012 1204 14 (1.16) 1445 15 (1.04) 0.89 (0.43–1.84) 2649 29 (1.09) 5955 108 (1.81) 0.60 (0.40–0.91)
 Total 3669 39 (1.06) 3667 50 (1.36) 1.28 (0.85–1.95) 7336 89 (1.21) 10,577 183 (1.73) 0.70 (0.55–0.90)
  1. Significant RRs are shown in bold font
  2. IVF in vitro fertilization, ICSI intracytoplasmic sperm injection, FET frozen-thawed embryo transfer, RR relative risk, 95 % CI 95 % confidence interval