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Table 2 Crude prevalence of birth defects and RR with 95 % CI according to the method of treatment by birth year period

From: Birth defects after assisted reproductive technology according to the method of treatment in Japan: nationwide data between 2004 and 2012

 

Fresh embryo transfer

FET

RR (95 % CI)

Fresh vs. FET

IVF

ICSI

RR (95 % CI)

ICSI vs. IVF

Total

Births

Prevalence (%)

Births

Prevalence (%)

Births

Prevalence (%)

Births

Prevalence (%)

2004–2006

19,785

139 (0.70)

17,309

153 (0.88)

1.26 (1.00–1.58)

37,094

292 (0.79)

20,068

114 (0.57)

1.39 (1.12–1.72)

2007–2009

14,957

184 (1.23)

15,095

223 (1.48)

1.20 (0.99–1.46)

30,052

407 (1.35)

38,342

503 (1.31)

1.03 (0.91–1.18)

2010–2012

14,028

211 (1.50)

16,267

234 (1.44)

0.96 (0.80–1.15)

30,295

445 (1.47)

69,487

964 (1.39)

1.06 (0.95–1.18)

Total

48,770

534 (1.09)

48,671

610 (1.25)

1.15 (1.02–1.29)

97,441

1144 (1.17)

127,897

1581 (1.24)

0.95 (0.88–1.02)

  1. Significant RRs are shown in bold font
  2. IVF in vitro fertilization, ICSI intracytoplasmic sperm injection, FET frozen-thawed embryo transfer, RR relative risk, 95 % CI 95 % confidence interval