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Table 2 Crude prevalence of birth defects and RR with 95 % CI according to the method of treatment by birth year period

From: Birth defects after assisted reproductive technology according to the method of treatment in Japan: nationwide data between 2004 and 2012

  Fresh embryo transfer FET RR (95 % CI)
Fresh vs. FET
IVF ICSI RR (95 % CI)
ICSI vs. IVF
Total
Births Prevalence (%) Births Prevalence (%) Births Prevalence (%) Births Prevalence (%)
2004–2006 19,785 139 (0.70) 17,309 153 (0.88) 1.26 (1.00–1.58) 37,094 292 (0.79) 20,068 114 (0.57) 1.39 (1.12–1.72)
2007–2009 14,957 184 (1.23) 15,095 223 (1.48) 1.20 (0.99–1.46) 30,052 407 (1.35) 38,342 503 (1.31) 1.03 (0.91–1.18)
2010–2012 14,028 211 (1.50) 16,267 234 (1.44) 0.96 (0.80–1.15) 30,295 445 (1.47) 69,487 964 (1.39) 1.06 (0.95–1.18)
Total 48,770 534 (1.09) 48,671 610 (1.25) 1.15 (1.02–1.29) 97,441 1144 (1.17) 127,897 1581 (1.24) 0.95 (0.88–1.02)
  1. Significant RRs are shown in bold font
  2. IVF in vitro fertilization, ICSI intracytoplasmic sperm injection, FET frozen-thawed embryo transfer, RR relative risk, 95 % CI 95 % confidence interval