Fig. 1

Body weight and voluntary exercise during the experimental period. Amount of voluntary exercise (A), body weight (B), and body weight gain before exercise and at 8 weeks (C) are shown. Circles and squares represent WT and db mice, respectively. Closed symbols represent exercising mice under the pair-fed condition (food amount consumed by ad libitum-fed WT mice was supplied). Open symbols represent ad libitum-fed mice under the sedentary condition. Hatched symbols represent pair-fed db mice under the sedentary condition (PSe-db mice). The values are the mean ± SE (A), the means − SE (B), or the means + SE (c), as appropriate. Values were analyzed by Student’s t test. In (A) and (B), ^a P < 0.05 vs. WT mice in each physical condition at the same time point. ^b P < 0.05 vs. ad-WT mice or PSe-db mice at the same time point. ^c P < 0.05 vs. ad-db mice at the same time point. In (C), ^a P < 0.05 vs. WT mice in each physical condition. ^b P < 0.05 vs. ad-WT mice or PSe-db mice. ^c P < 0.05 vs. ad-db mice